Evidence map›Paper›PMID 42153522›Full record

ReviewJournal of immunology (Baltimore, Md. : 1950)2026

From the gene to the clinic: Key milestones in the PI3Kδ journey.

Bart Vanhaesebroeck

Abstract readReview
In one paragraph

Review in Journal of immunology (Baltimore, Md. : 1950), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Bart VanhaesebroeckUCL Cancer Institute, University College London, London, United Kingdom.

Funding

Cancer Research UK C23338/A15965Cancer Research UK C23338/A25722European UnionEuropean Union's Horizon 2020 Research and Innovation Programme under Marie Skłodowska-Curie 955534Klaus Okkenhaug and Sara Al-Jarrah SetoLudwig Institute for Cancer Research, Cancer Research UKSarah Conduit and Klaus OkkenhaugUK Research and Innovation (Biotechnology and Biological Sciences Research Council, Medical Research Council)
6 · The paper itself

Abstract

Among the PI3K isoforms, PI3Kδ has attracted particular attention from immunologists and hematologists. Despite earlier clinical setbacks, the PI3Kδ field has recently re-emerged with renewed promise. Here, I highlight key milestones in the evolving understanding of PI3Kδ signaling in immunity and cancer, and pivotal studies that have shaped this field.

Indexed as

Class I Phosphatidylinositol 3-KinasesNeoplasmsPhosphatidylinositol 3-KinasesAnimalsHumansSignal TransductionClass I Phosphatidylinositol 3-KinasesPhosphatidylinositol 3-KinasesPI3K, PI 3-kinase, signaling, cancer, leukemia, lymphoma, drug, medicine

Identifiers

PMID42153522
PMCPMC13184825

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.