ArticleActa physiologica (Oxford, England)2026
Mechanism of Fluid Reabsorption in Kidney Proximal Tubule: Interplay Between Lateral Na
Article in Acta physiologica (Oxford, England), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Integrative multi-omics analysis prioritizes compartment-specific candidate targets of gut microbiota metabolites in diabetic kidney disease.Frontiers in immunology · 2026Article
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2 authors.
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Abstract
aimsThe mechanism of isosmotic water reabsorption in the kidney proximal tubule, with a focus on the interaction between the lateral Na
methodsA mathematical model of proximal tubular transport was used to compute coupled ion, solute, and water fluxes. The model included apical ENaC and a full electrogenic Na
resultsPublished cellular cation concentrations indicate metabolic stress in excised tubules, providing biophysical rationale for interpreting enhanced NHE3 activity and proton secretion in isolated proximal tubules as consequences of reduced ΔG
conclusionProximal tubular water reabsorption is not explained by passive osmotic equilibration alone, but emerges from thermodynamic coupling between active Na
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