Evidence map›Paper›PMID 42153200›Full record

ArticleMultiple sclerosis journal - experimental, translational and clinical

Myelin damage in radiologically isolated syndrome is associated with decreased processing speed.

Olivia Kalau, Poljanka Johnson, Jiwon Oh, Alexandre Prat, Irene M Vavasour, Cornelia Laule, Roger Tam, Connor Keane, Sarah A Morrow, Jeffrey Wilken and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Multiple sclerosis journal - experimental, translational and clinical. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Olivia KalauORCID https://orcid.org/0000-0001-8611-8808
Poljanka JohnsonDepartment of Medicine (Neurology), University of British Columbia, Vancouver, Canada.ORCID https://orcid.org/0000-0003-4153-428X
Jiwon OhDivision of Neurology, Department of Medicine, St Michael's Hospital, University of Toronto, Toronto, Canada.
Alexandre PratDepartment of Neurosciences, Université de Montréal and Centre hospitalier de l'Université de Montréal, Montreal, Canada.
Irene M VavasourDepartment of Radiology, University of British Columbia, Vancouver, Canada.ORCID https://orcid.org/0000-0001-9286-0953
Cornelia LauleDepartment of Radiology, University of British Columbia, Vancouver, Canada.ORCID https://orcid.org/0000-0002-9785-6918
Roger TamSchool of Biomedical Engineering, University of British Columbia, Vancouver, Canada.
Connor KeaneDepartment of Medicine (Neurology), University of British Columbia, Vancouver, Canada.
Sarah A MorrowDepartment of Clinical Neurological Sciences, Hotchkiss Brain Institute, University of Calgary, Calgary, Canada.ORCID https://orcid.org/0000-0001-7522-6440
Jeffrey WilkenDepartment of Neurology, Georgetown University Hospital, Washington, USA.
Alice SchabasDepartment of Medicine (Neurology), University of British Columbia, Vancouver, Canada.
Larry D LyndFaculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, Canada.
Scott B PattenDepartment of Community Health Sciences, University of Calgary, Calgary, Canada.
Alan H WilmanDepartment of Radiology and Diagnostic Imaging, University of Alberta, Edmonton, Canada.
Yunyan ZhangDepartment of Radiology & Clinical Neurosciences, University of Calgary, Calgary, Canada.
V Wee YongDepartment of Clinical Neurosciences and the Hotchkiss Brain Institute, University of Calgary, Calgary, Canada.
Shannon H KolindDepartment of Medicine (Neurology), University of British Columbia, Vancouver, Canada.ORCID https://orcid.org/0000-0003-1362-1968
Anthony L TraboulseeDepartment of Medicine (Neurology), University of British Columbia, Vancouver, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Cognitive impairment (CI) is a common feature of multiple sclerosis (MS). Radiologically isolated syndrome (RIS) can demonstrate CI patterns similar to MS, providing an opportunity to explore the associations between CI and early stage disease pathology. Objectives: To investigate myelin damage in RIS normal appearing white matter (NAWM) using the myelin heterogeneity index (MHI) and to determine the relationship between MHI and processing speed. Methods: A total of 28 people with RIS and 22 controls completed an MRI, including multi-component T Results: CC NAWM MHI was higher in RIS versus controls (indicative of myelin damage, Conclusion: Diffuse myelin damage was detected in RIS NAWM, along with associations between increased damage and slower processing speed, suggesting a potential pathological mechanism for RIS-related CI.

Indexed as

cognitionmagnetic resonance imagingMyelinradiologically isolated syndrome

Identifiers

PMID42153200
PMCPMC13180136

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.