ArticlePeerJ2026
Integrated analysis of programmed cell death-related genes identifies CORO1A as an apoptosis-associated gene in acute myeloid leukemia.
Article in PeerJ, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
7 authors.
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Abstract
Background: Programmed cell death (PCD) governs tissue homeostasis and shapes tumor-immune interactions. In acute myeloid leukemia (AML), apoptosis evasion drives resistance and poor outcomes, yet the PCD landscape and the role of Coronin 1A (CORO1A) remain insufficiently defined. Methods: We integrated AML bone marrow single-cell RNA-seq (GSE154109) with bulk RNA-seq from TCGA (training) and GSE71014 (testing), and GTEx normal marrow. After batch correction, we profiled 3,524 PCD- related genes. Single-cell analyses (Seurat, Harmony) resolved hematopoietic and malignant populations; pathway activity was quantified by ssGSEA/GSVA. Survival modeling used a multi-algorithm framework (10 learners, 117 combinations). Immune features were inferred Results: Malignant cells and monocytes/macrophages showed higher PCD enrichment than lymphoid clusters. Malignant cells upregulated MYC/E2F targets, DNA repair, fatty acid metabolism, with attenuated interferon signaling. From 3,524 genes, we derived a five-gene prognostic signature-CORO1A and PECAM1 (risk), and CLEC11A, ITGA4, AGTPBP1 (protective)- Conclusions: Multi-omic integration of PCD-related genes delineates PCD-driven heterogeneity in AML and yields a robust five-gene prognostic model with therapeutic implications. CORO1A emerges as a potential apoptosis-associated oncogene that promoting AML cell survival.
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