Evidence map›Paper›PMID 42152881›Full record

ArticleInfection and drug resistance2026

Combination Therapy with Ceftazidime-Avibactam, Aztreonam, and Topical Polymyxin B for NDM-Producing

Guanghong Qi, Wenkai Cong, Mingda Zhang, Shengjie Wang, Zhenwei Bai, Biao Li, Hongwei Chen

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Infection and drug resistance, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Guanghong QiCerebrospinal Fluid Disease Department, Aviation General Hospital, Beijing, People's Republic of China.ORCID 0009-0001-8792-4796
Wenkai CongCerebrospinal Fluid Disease Department, Aviation General Hospital, Beijing, People's Republic of China.
Mingda ZhangCerebrospinal Fluid Disease Department, Aviation General Hospital, Beijing, People's Republic of China.
Shengjie WangCerebrospinal Fluid Disease Department, Aviation General Hospital, Beijing, People's Republic of China.
Zhenwei BaiCerebrospinal Fluid Disease Department, Aviation General Hospital, Beijing, People's Republic of China.
Biao LiCerebrospinal Fluid Disease Department, Aviation General Hospital, Beijing, People's Republic of China.
Hongwei ChenCerebrospinal Fluid Disease Department, Aviation General Hospital, Beijing, People's Republic of China.ORCID 0000-0003-2843-1577

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Central nervous system (CNS)-associated infections caused by carbapenem-resistant Case Presentation: A 61-year-old man developed a severe postoperative CNS infection following decompressive craniectomy for cerebellar infarction. The initial microbiology report from a previous hospital identified a KPC-positive, NDM-negative Conclusion: This case illustrates the diagnostic importance of repeat carbapenemase testing in refractory CNS infections and suggests that combined ceftazidime-avibactam plus aztreonam, with adjunctive topical polymyxin B, may be a useful therapeutic strategy for CZA-resistant, KPC- and NDM-co-producing

Indexed as

aztreonamcarbapenem-resistant Enterobacteralesceftazidime–avibactamCNS infectionKPC-producing Klebsiella pneumoniaeNDM-producing Klebsiella pneumoniaepolymyxin B

Identifiers

PMID42152881
PMCPMC13180328

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.