Evidence map›Paper›PMID 42152879›Full record

ArticleInfection and drug resistance2026

Thrombosis in Severe Influenza A Pneumonia: Distribution and Risk Factors in Hangzhou, China.

Nannan Ma, Qing Pan, YuanYuan Qi, FengLin Shao

Abstract read
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Article in Infection and drug resistance, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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4 · The record

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5 · Who and what money

Authors and funding

4 authors.

Nannan MaDepartment of Nursing, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310003, People's Republic of China.
Qing PanDepartment of Nursing, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310003, People's Republic of China.
YuanYuan QiDepartment of Nursing, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310003, People's Republic of China.
FengLin ShaoDepartment of Nursing, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310003, People's Republic of China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Severe viral pneumonia, including that caused by influenza A, can trigger a systemic inflammatory response that can lead to coagulation abnormalities, which substantially increases the risk of life-threatening thrombotic complications. Objective: This study aimed to examine the distribution of thrombosis and its risk factors among patients with severe influenza A pneumonia to inform early clinical identification and intervention. Methods: A retrospective analysis was performed on 175 patients with severe influenza A pneumonia who were admitted to the Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital, Zhejiang University School of Medicine between January 2024 and March 2025. Patients were categorised into a thrombosis group (n = 82) and a control group (n = 93). Clinical data were analysed using univariate and multivariate logistic regression to identify independent risk factors. Results: The thrombosis group showed significantly higher D-dimer (3.06 [0.95, 12.42] vs 0.90 [0.54, 1.53] μg/mL, Conclusion: This study clarified that venous thrombosis, predominantly IMVT and pulmonary embolism, is the primary thrombotic complication in severe influenza A pneumonia. We identified a unique biomarker profile for risk stratification; elevated D-dimer and decreased haemoglobin are independent risk factors, whereas prolonged PT was independently associated with a lower risk of thrombosis. This combination provides a practical tool for early clinical identification of patients at high risk, guiding tailored thromboprophylaxis.

Indexed as

D-dimerinfluenza A virusrisk factorsevere pneumoniavenous thrombus

Identifiers

PMID42152879
PMCPMC13180384

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