ReviewChemistryOpen2026
Recent Advances in Intramolecular C─N Bond Formation for Pyrrolidine Synthesis.
Review in ChemistryOpen, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Pyrrolidines constitute a privileged class of nitrogen heterocycles that are ubiquitous in pharmaceuticals, bioactive molecules, and functional materials, thereby continuing to stimulate the development of efficient and versatile synthetic strategies. Among these, intramolecular C─N bond formation represents one of the most fundamental and broadly applicable approaches for the construction of pyrrolidine frameworks. Despite its central importance, a systematic overview focusing specifically on this ring-closing paradigm has been lacking. This review summarizes key advances reported between 2013 and 2025 in the synthesis of pyrrolidines via intramolecular C─N bond formation, focusing specifically on examples featuring a polar ring-closure step N: → C(+/δ
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