ArticleThoracic cancer2026
Trends in the Overall Incidence and Mortality of Lung Cancer: An Extensive Longitudinal Study Utilizing the CDC WONDER Database 1999-2020.
Article in Thoracic cancer, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundLung cancer remains a leading cause of global mortality despite declining rates. Since 2010, FDA-approved immune checkpoint inhibitors (ICIs) have transformed treatment. This study investigates lung cancer incidence and mortality trends, emphasizing temporal associations with ICI integration and smoking patterns. MATERIALS AND
methodsData (1999-2020) were extracted from the CDC WONDER database. Trends were analyzed using joinpoint regression to determine the annual percent change (APC).
resultsLung cancer incidence declined from 1999 to 2020, with the sharpest decrease post-2018 (APC -6.90) compared to 2006-2018 (APC -1.78). Males saw steeper declines than females; however, American Indians/Alaska Natives showed an increasing trend (APC 3.96). Smoking prevalence decreased overall (1965-2018), though youth smoking rose between 1992 and 2004. By 2018, smoking was highest among American Indians/Alaska Natives (25.9%). Lung cancer mortality declined steadily since 1999, accelerating after 2014 (APC -4.10). Conversely, cardiovascular (CVS) mortality decline decelerated after 2015, stabilizing between 2018 and 2020 (APC 0.82; 95% CI -0.53 to 1.81).
conclusionLung cancer incidence and mortality declined significantly over two decades. The accelerated mortality declines post-2014 coincide with the clinical integration of ICIs. The stabilization of CVS mortality after 2015 reflects a shift in the clinical profile, potentially related to competing risks and ICI-related trends, warranting further investigation into whether population-level CVS mortality is influenced by immunotherapy.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.