Evidence map›Paper›PMID 42152695›Full record

ArticleJournal of animal physiology and animal nutrition2026

Beyond Immunity: Functional Outcomes of Dietary Yeast and Seaweed β-Glucans in Adult Canine Nutrition.

Stephanie de Souza Theodoro, Maria Eduarda Gonçalves Tozato, Letícia Warde Luis, Camila Goloni, Jhennifer de Castro Fenerick, Lucas Bassi Scarpim, Isabel Ten Caten Bento, Connie Abril Rojas, Marcelino Bortolo, Aulus Cavalieri Carciofi

Abstract readRandomized Controlled Trial, Veterinary
In one paragraph

Article in Journal of animal physiology and animal nutrition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Stephanie de Souza TheodoroDepartment of Animal Science, College of Animal Science and Food Engineering, University of São Paulo, Pirassununga, Brazil.ORCID https://orcid.org/0000-0001-8075-458X
Maria Eduarda Gonçalves TozatoVeterinary Medicine and Surgery Department, School of Agricultural and Veterinarian Sciences, São Paulo State University, Jaboticabal, Brazil.
Letícia Warde LuisVeterinary Medicine and Surgery Department, School of Agricultural and Veterinarian Sciences, São Paulo State University, Jaboticabal, Brazil.ORCID https://orcid.org/0000-0002-3990-6673
Camila GoloniVeterinary Medicine and Surgery Department, School of Agricultural and Veterinarian Sciences, São Paulo State University, Jaboticabal, Brazil.
Jhennifer de Castro FenerickVeterinary Medicine and Surgery Department, School of Agricultural and Veterinarian Sciences, São Paulo State University, Jaboticabal, Brazil.
Lucas Bassi ScarpimVeterinary Medicine and Surgery Department, School of Agricultural and Veterinarian Sciences, São Paulo State University, Jaboticabal, Brazil.
Isabel Ten Caten BentoVeterinary Medicine and Surgery Department, School of Agricultural and Veterinarian Sciences, São Paulo State University, Jaboticabal, Brazil.
Connie Abril RojasAnimalBiome, Oakland, California, USA.ORCID https://orcid.org/0000-0002-6097-8970
Marcelino BortoloKemin Industries, Inc., São Paulo, Brazil.
Aulus Cavalieri CarciofiVeterinary Medicine and Surgery Department, School of Agricultural and Veterinarian Sciences, São Paulo State University, Jaboticabal, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

β-Glucans are functional compounds associated with health benefits; however, the physiological effects of different β-glucan sources in dog foods remain incompletely understood. This study evaluated and compared the effects of β-glucans derived from Euglena gracilis (seaweed) and Saccharomyces cerevisiae (yeast) on nutrient digestibility, fermentation products, faecal microbiota composition, serum lipid profile, and postprandial glucose and insulin responses in healthy adult dogs fed extruded diets. A single basal diet was used across four treatments: CON (control, no β-glucan), B-Y15 (0.115% yeast β-glucan), B-S15 (0.155% seaweed β-glucan) and B-S30 (0.310% seaweed β-glucan), formulated to provide daily intakes of 15 or 30 mg β-glucan/kg body weight/day. Thirty-two adult Beagle dogs were allocated to a randomised block design (n = 8 per treatment), with each experimental block consisting of a 42-day washout period followed by a 42-day treatment period. Apparent nutrient digestibility, faecal fermentation products, serum lipid profile, postprandial glucose and insulin responses, and faecal microbiota composition (16S rRNA gene sequencing) were evaluated. Data were analysed using ANOVA, Tukey's, and repeated measures (p < 0.05). Low levels of E. gracilis β-glucans improved apparent digestibility of dietary gross energy. Supplementation with either β-glucan sources did not significantly alter postprandial lipid parameters or glucose responses; however, a high dose of seaweed-derived β-glucan delayed the insulin peak. Higher inclusion levels of seaweed β-glucans were associated with alterations in overall faecal microbiota community structure, as indicated by beta-diversity analysis, without corresponding changes in species richness, evenness, or faecal fermentation products. In conclusion, β-glucans from yeast and seaweed exhibited distinct physiological effects in healthy adult dogs. Moderate inclusion of seaweed-derived β-glucans enhanced nutrient utilization, whereas higher inclusion levels influenced insulin kinetics and faecal microbiota community structure. These findings underscore the importance of β-glucan source and inclusion level when considering their application as functional ingredients in canine nutrition.

Indexed as

Animal Feedbeta-GlucansDietSaccharomyces cerevisiaeSeaweedAnimal Nutritional Physiological PhenomenaAnimalsDogsEuglena gracilisFecesFemaleMalebeta-GlucansEuglena gracilisinsulinmicrobiotaSaccharomyces cerevisiae

Identifiers

PMID42152695
PMCPMC13576554

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.