Evidence map›Paper›PMID 42152464›Full record

ArticleNMR in biomedicine2026

Ferumoxytol-Enhanced Myocardial T1 Tracking Using a Hybrid 2D/3D Steady-State MRI Sequence Captures Cyclic Intramyocardial Blood Volume Dynamics.

Hazar Benan Unal, Shahriar Zeynali, Abdul Ahmed, Eric Anttila, Ronald Mastouri, Rolf P Kreutz, Rohan Dharmakumar, David C Gross, Behzad Sharif

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NMR in biomedicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Hazar Benan UnalLaboratory for Translational Imaging of Microcirculation, Purdue University, Indianapolis, Indiana, USA.ORCID https://orcid.org/0009-0009-2642-1835
Shahriar ZeynaliLaboratory for Translational Imaging of Microcirculation, Purdue University, Indianapolis, Indiana, USA.
Abdul AhmedMR R&D Collaborations, Siemens Medical Solutions USA, Indianapolis, Indiana, USA.
Eric AnttilaMED Institute, West Lafayette, Indiana, USA.
Ronald MastouriDivision of Cardiovascular Medicine, Indiana Univ. School of Medicine, Indianapolis, Indiana, USA.
Rolf P KreutzDivision of Cardiovascular Medicine, Indiana Univ. School of Medicine, Indianapolis, Indiana, USA.ORCID https://orcid.org/0000-0002-2110-607X
Rohan DharmakumarWeldon School of Biomedical Engineering, Purdue University, West Lafayette, Indiana, USA.
David C GrossMED Institute, West Lafayette, Indiana, USA.
Behzad SharifLaboratory for Translational Imaging of Microcirculation, Purdue University, Indianapolis, Indiana, USA.ORCID https://orcid.org/0000-0002-8945-8178

Funding

Lilly Endowment Inc.NHLBI NIH HHS R01-HL153430
6 · The paper itself

Abstract

Measuring cyclic changes in intramyocardial blood volume (iMBV) from systole to diastole has been used as an imaging marker for assessing coronary microcirculation and detecting coronary artery disease (CAD) without the need for vasodilator stress. However, an MRI-based method for detecting cyclic iMBV dynamics does not exist. The aim of this study is to demonstrate the feasibility of using ferumoxytol-enhanced (FE) MRI to detect systolic-to-diastolic iMBV dynamics on clinical scanners enabled by a new myocardial "T1 tracking" technique. To this end, a continuous steady-state sequence was developed, combining slice/slab-selective excitation, to generate high-resolution T1-weighted images such that the myocardial signal dynamically tracks the fractional volume of blood while minimizing the influence of confounding factors such as in-flow effects, through-plane motion, and spin history. In addition to phantom studies, FE studies in swine (n = 10) were conducted to generate systolic/diastolic T1 maps from the T1-tracking data. For comparison, MOLLI T1 maps were acquired. For both the T1-tracking method and MOLLI, T1 values before/after ferumoxytol were used to calculate iMBV at end-systole (ES) and end-diastole (ED). The T1-tracking method showed a significant iMBV difference between ES and ED (ES: 6.2 ± 1.8%, ED: 7.7 ± 2.0%, p < 10

Indexed as

Blood VolumeFerrosoferric OxideHeartImaging, Three-DimensionalMagnetic Resonance ImagingMyocardiumAnimalsContrast MediaPhantoms, ImagingSwineContrast MediaFerrosoferric Oxideblood volumecardiac cyclecardiac magnetic resonancecoronary artery diseaseferumoxytolischemic heart diseasemyocardial MRIspoiled gradient echo

Identifiers

PMID42152464
PMCPMC13184369

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.