Evidence map›Paper›PMID 42152453›Full record

Trial reportBMJ open2026

Feasibility, acceptability and efficacy of a nurse-led palliative care health coaching intervention (Educate, Nurture, Advise before Life Ends) for patients with heart failure and their caregivers in Singapore: a randomised wait-list controlled pilot study of health coaching in Asian heart failure.

Shirlyn Hui-Shan Neo, Whee Sze Ong, Kehua Liao, David Kheng-Leng Sim, Elaine Swee Ling Ng, Cherylyn Chun-Zhen Foo, Grace Yang Meijuan, J Nicholas Odom, Marie Bakitas, Yin Bun Cheung

Registry-linked trialAbstract readRandomized Controlled TrialClinical Trial, Phase II
In one paragraph

Trial report in BMJ open, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05211882 (Pilot Wait-list Randomized Controlled Trial of the ENABLE), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05211882 nacompletednot on this map

Pilot Wait-list Randomized Controlled Trial of the ENABLE (Educate, Nurture, Advise, Before Life Ends) Intervention for Heart Failure (HF) Patients and Their Caregivers in Singapore

TypeinterventionalSponsorNational Cancer Centre, SingaporeRan2022 to 2024Enrolled125ConditionsHeart FailureArmsImmediate ENABLE nurse coaching, on top of usual care, Usual Care
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Shirlyn Hui-Shan NeoDivision of Supportive and Palliative Care, National Cancer Centre, Singapore shirlyn.neo.h.s@singhealth.com.sg.ORCID http://orcid.org/0000-0003-2811-1661
Whee Sze OngDivision of Clinical Trials and Epidemiological Sciences, National Cancer Centre, Singapore.
Kehua LiaoNursing Service, Woodlands Health, Singapore.
David Kheng-Leng SimCardiology, National Heart Centre Singapore, Singapore.
Elaine Swee Ling NgNursing Specialty Care Unit, National Heart Centre Singapore, Singapore.
Cherylyn Chun-Zhen FooDivision of Supportive and Palliative Care, National Cancer Centre, Singapore.
Grace Yang MeijuanDivision of Supportive and Palliative Care, National Cancer Centre, Singapore.
J Nicholas OdomSchool of Nursing, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Marie BakitasSchool of Nursing, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Yin Bun CheungGlobal Health Group, Tampere Universities, Tampere, Finland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo evaluate the feasibility, acceptability and potential efficacy of the culturally adapted Educate, Nurture, Advise Before Life Ends (ENABLE) programme in Singapore for patients with heart failure (HF) and their family caregivers.

designNon-blinded randomised wait-list controlled pilot study, using Simon's randomised phase II trial design.

settingSpecialist outpatient clinics in a tertiary cardiac centre in Singapore.

participantsPatients had a diagnosis of American Heart Association Stage C or D HF, were symptomatic with New York Heart Association functional class 2 and above symptoms, had a prognosis of 6 months, a hospitalisation in prior 6 months and were on disease-directed HF management. Patients already known to palliative care (PC) were excluded. Recruited caregivers were family caregivers of patients.

interventionENABLE integrates PC early into HF care. It starts with a comprehensive PC assessment with a PC physician and nurse. This is followed by a series of nurse coach-led health coaching sessions for both patients and caregivers. After the completion of health coaching, participants would receive follow-up phone calls to review their coping up to 6 months post-enrolment. OUTCOME MEASURES:

results

conclusionsProportion of participants who completed health coaching was high, though proportion of approached participants who consented was lower than expected. Our acceptability and efficacy targets were met. Further phase III testing is planned. TRIAL REGISTRATION NUMBER: NCT05211882.

Indexed as

CaregiversHeart FailureMentoringPalliative CarePatient Education as TopicAdaptation, PsychologicalAgedFeasibility StudiesFemaleHumansMaleMiddle AgedPatient Acceptance of Health CarePilot ProjectsQuality of LifeSingaporeCaregiversHeart failurePALLIATIVE CAREPatients

Identifiers

PMID42152453
PMCPMC13182425

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.