ArticleAdvanced healthcare materials2026
Coaxially Electrospun Myocardial dECM- Based Nanofibrous Scaffolds Demonstrate Enhanced Cardiomyocyte Biocompatibility.
Article in Advanced healthcare materials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
Abstract
The limited regenerative capability of mature cardiomyocytes (CMs) makes myocardial repair more challenging, requiring effective and viable alternatives to conventional heart transplants. Cardiac tissue engineering is a substitutionary approach combining cells, scaffolds, and growth factors to develop functional heart tissues in vitro. Induced pluripotent stem cells (iPSCs) represent a significant advancement in cardiac regenerative medicine, offering a continuous supply of CMs, however, the limited understanding of their microenvironment hinders translational research. Decellularized extracellular matrix (dECM) derived from myocardium is a highly promising natural scaffold for CTE, given its tissue-specific composition, mechanical properties, and biochemical cues that promote cellular regeneration. This study investigates myocardial dECM-based fibrous scaffolds for iPSC-derived CM use. Coaxially electrospun nanofibers comprising a polyurethane core and a blend of polycaprolactone and myocardial dECM as the sheath were optimized. Morphological analysis confirms the resemblance of the nanofibers to fibrillar collagen in the native dECM. ATR- FTIR and immunostaining results confirm the presence of dECM, which enhanced their hydrophilicity and enzymatic degradation. Biocompatibility results show higher phenotypic retention of iPSC-CMs due to microenvironments enriched with native proteins. On the contrary, the scaffolds without myocardial proteins exhibit higher dedifferentiation of iPSC-CMs, proving that ECM proteins provide a suitable microenvironment for iPSC-CMs.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.