Evidence map›Paper›PMID 42152079›Full record

ArticleLaboratory animal research2026

Application of exosomes derived from human umbilical cord stem cells in the treatment of ovalbumin-induced allergic asthma in mice.

Yong Ding, Yanli Zhang, Qi Cao, Yong Yin, Zhenglai Ma, Wenxia Pan, Xinjie Du, Chunling Ma

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Laboratory animal research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yong Ding *Key Laboratory of Birth Defect Prevention and Control, Women's and Children's Health Care Hospital of Linyi, Linyi, Shandong, 276000, China.
Yanli Zhang *Key Laboratory of Birth Defect Prevention and Control, Women's and Children's Health Care Hospital of Linyi, Linyi, Shandong, 276000, China.
Qi CaoKey Laboratory of Birth Defect Prevention and Control, Women's and Children's Health Care Hospital of Linyi, Linyi, Shandong, 276000, China.
Yong YinDepartment of Medical Laboratory, Shandong Pharmaceutical and Food Vocational College, Weihai, Shandong, 264210, China.
Zhenglai MaKey Laboratory of Birth Defect Prevention and Control, Women's and Children's Health Care Hospital of Linyi, Linyi, Shandong, 276000, China.
Wenxia PanKey Laboratory of Birth Defect Prevention and Control, Women's and Children's Health Care Hospital of Linyi, Linyi, Shandong, 276000, China.
Xinjie DuKey Laboratory of Birth Defect Prevention and Control, Women's and Children's Health Care Hospital of Linyi, Linyi, Shandong, 276000, China.
Chunling MaKey Laboratory of Birth Defect Prevention and Control, Women's and Children's Health Care Hospital of Linyi, Linyi, Shandong, 276000, China. machl2003@163.com.ORCID http://orcid.org/0000-0002-7651-3860

Funding

1.Women,s and Children,s Health Care Hospital of Linyi 120,000.00RMB
6 · The paper itself

Abstract

backgroundThis study investigated the therapeutic potential of exosomes derived from human umbilical cord mesenchymal stem cells (hUCMSCs-exos) in an Ovalbumin (OVA) -induced mouse model of allergic asthma, comparing their efficacy to budesonide, a standard asthma treatment. hUCMSCs-exos were characterized by their typical morphology, size, and marker expression (CD9, CD63, and HSP70) using transmission electron microscopy (TEM), Nanosight 300, and Western blot analysis.

resultsTreatment with hUCMSCs-exos significantly decreased lung inflammation by detecting plasma IL-4 and IgE levels, as well as white blood cells and eosinophils counts in Bronchoalveolar lavage fluid (BALF), the M1 and M2 type of macrophages, Regulatory T Cells (Tregs) in lung tissues, paralleling the effects of budesonide therapy. Notably, hUCMSCs -exos achieved a greater reduction in the percentage of eosinophils in BALF and a significant increase M2 macrophages and Tregs in lung tissues.

conclusionsThese findings suggest hUCMSCs-exos may offer comparable or superior therapeutic benefits to budesonide, warranting further investigation into their molecular mechanisms to support clinical application.

Indexed as

Allergic asthmaBudesonideExosomesHuman umbilical cord mesenchymal stem cellsMouse models

Identifiers

PMID42152079
PMCPMC13182008

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.