Evidence map›Paper›PMID 42152013›Full record

ReviewJournal of translational medicine2026

Glycolysis-driven cancer-associated fibroblasts shape T-Cell exclusion via the CXCL16-CXCR6 Axis: a metabolic-chemokine mechanism in tumor immunity.

Yunya Liu, Chutong Xiong, Guichen Huang, Menghao Xu, JinXiao Li, Minfeng Zhou, Fengxia Liang, Rui Chen

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of translational medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yunya Liu *Department of Integrated Traditional Chinese and Western Medicine, Union Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430000, Hubei, China.
Chutong Xiong *Department of Integrated Traditional Chinese and Western Medicine, Union Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430000, Hubei, China.
Guichen Huang *Department of Integrated Traditional Chinese and Western Medicine, Union Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430000, Hubei, China.
Menghao XuDepartment of Integrated Traditional Chinese and Western Medicine, Union Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430000, Hubei, China.
JinXiao LiDepartment of Integrated Traditional Chinese and Western Medicine, Union Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430000, Hubei, China.
Minfeng ZhouDepartment of Integrated Traditional Chinese and Western Medicine, Union Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430000, Hubei, China. mfzhou_ys@163.com.
Fengxia LiangSchool of Acupuncture and Bone Injury, Hubei University of Chinese Medicine, Wuhan, 430060, Hubei, China. fxliang5@hotmail.com.
Rui ChenDepartment of Integrated Traditional Chinese and Western Medicine, Union Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430000, Hubei, China. unioncr@163.com.ORCID 0000-0002-1587-0362

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundImmune-excluded tumors are characterized by abundant CD8 MAIN BODY: This review highlights a glycolysis-driven CAFs (glyCAFs) pathway that orchestrates immune exclusion. Glycolysis CAFs upregulate Glucose Transporter 1 (GLUT1) to sustain CXCL16 secretion, which in turn engages CXCR6 on CD8

conclusionsThe glyCAF-GLUT1-CXCL16-CXCR6 axis establishes a clear mechanistic and translational framework linking stromal metabolism to immune spatial architecture, paving the way for precision immunometabolic strategies to overcome T-cell exclusion in solid tumors.

Indexed as

Cancer-Associated FibroblastsChemokine CXCL16ChemokinesGlycolysisNeoplasmsReceptors, CXCR6T-LymphocytesAnimalsHumansSignal TransductionChemokine CXCL16ChemokinesCXCR6 protein, humanReceptors, CXCR6Cancer-associated fibroblastsCombined immunotherapy for CancerCXCL16CXCR6GLUT1GlyCAFImmune exclusion

Identifiers

PMID42152013
PMCPMC13360483

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.