Evidence map›Paper›PMID 42151946›Full record

ArticleBMC veterinary research2026

Epidemiological and genetic variation analysis of emerging porcine circovirus type 3 in Henan Province, 2023-2024.

Jiajing Song, Hongyue Zhai, Jiajia Cao, Mengtian Jia, Jiabao Wang, Yingying Zhao, Yu Zhang, Linyue Xiao, Tianyu Jia, Na Li and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC veterinary research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Jiajing SongHenan Province Engineering Technology Research Center of Animal Disease Diagnosis and Integrated Control, Henan Key Laboratory of Insect Biology, Henan Province Engineering Research Center of Insect Bioreactor, China-UK International Joint Laboratory for Insect Biology of Henan Province, Nanyang Normal University, Nanyang, PR China.
Hongyue ZhaiHenan Province Engineering Technology Research Center of Animal Disease Diagnosis and Integrated Control, Henan Key Laboratory of Insect Biology, Henan Province Engineering Research Center of Insect Bioreactor, China-UK International Joint Laboratory for Insect Biology of Henan Province, Nanyang Normal University, Nanyang, PR China.
Jiajia CaoHenan Province Engineering Technology Research Center of Animal Disease Diagnosis and Integrated Control, Henan Key Laboratory of Insect Biology, Henan Province Engineering Research Center of Insect Bioreactor, China-UK International Joint Laboratory for Insect Biology of Henan Province, Nanyang Normal University, Nanyang, PR China.
Mengtian JiaHenan Province Engineering Technology Research Center of Animal Disease Diagnosis and Integrated Control, Henan Key Laboratory of Insect Biology, Henan Province Engineering Research Center of Insect Bioreactor, China-UK International Joint Laboratory for Insect Biology of Henan Province, Nanyang Normal University, Nanyang, PR China.
Jiabao WangHenan Province Engineering Technology Research Center of Animal Disease Diagnosis and Integrated Control, Henan Key Laboratory of Insect Biology, Henan Province Engineering Research Center of Insect Bioreactor, China-UK International Joint Laboratory for Insect Biology of Henan Province, Nanyang Normal University, Nanyang, PR China.
Yingying ZhaoHenan Province Engineering Technology Research Center of Animal Disease Diagnosis and Integrated Control, Henan Key Laboratory of Insect Biology, Henan Province Engineering Research Center of Insect Bioreactor, China-UK International Joint Laboratory for Insect Biology of Henan Province, Nanyang Normal University, Nanyang, PR China.
Yu ZhangHenan Province Engineering Technology Research Center of Animal Disease Diagnosis and Integrated Control, Henan Key Laboratory of Insect Biology, Henan Province Engineering Research Center of Insect Bioreactor, China-UK International Joint Laboratory for Insect Biology of Henan Province, Nanyang Normal University, Nanyang, PR China.
Linyue XiaoHenan Province Engineering Technology Research Center of Animal Disease Diagnosis and Integrated Control, Henan Key Laboratory of Insect Biology, Henan Province Engineering Research Center of Insect Bioreactor, China-UK International Joint Laboratory for Insect Biology of Henan Province, Nanyang Normal University, Nanyang, PR China.
Tianyu JiaHenan Province Engineering Technology Research Center of Animal Disease Diagnosis and Integrated Control, Henan Key Laboratory of Insect Biology, Henan Province Engineering Research Center of Insect Bioreactor, China-UK International Joint Laboratory for Insect Biology of Henan Province, Nanyang Normal University, Nanyang, PR China.
Na LiHenan Province Engineering Technology Research Center of Animal Disease Diagnosis and Integrated Control, Henan Key Laboratory of Insect Biology, Henan Province Engineering Research Center of Insect Bioreactor, China-UK International Joint Laboratory for Insect Biology of Henan Province, Nanyang Normal University, Nanyang, PR China.
Teng ZhangHenan Province Engineering Technology Research Center of Animal Disease Diagnosis and Integrated Control, Henan Key Laboratory of Insect Biology, Henan Province Engineering Research Center of Insect Bioreactor, China-UK International Joint Laboratory for Insect Biology of Henan Province, Nanyang Normal University, Nanyang, PR China.
Hongfei ShiHenan Province Engineering Technology Research Center of Animal Disease Diagnosis and Integrated Control, Henan Key Laboratory of Insect Biology, Henan Province Engineering Research Center of Insect Bioreactor, China-UK International Joint Laboratory for Insect Biology of Henan Province, Nanyang Normal University, Nanyang, PR China.
Dandan LiHenan Province Engineering Technology Research Center of Animal Disease Diagnosis and Integrated Control, Henan Key Laboratory of Insect Biology, Henan Province Engineering Research Center of Insect Bioreactor, China-UK International Joint Laboratory for Insect Biology of Henan Province, Nanyang Normal University, Nanyang, PR China.
Yunchao KanHenan Province Engineering Technology Research Center of Animal Disease Diagnosis and Integrated Control, Henan Key Laboratory of Insect Biology, Henan Province Engineering Research Center of Insect Bioreactor, China-UK International Joint Laboratory for Insect Biology of Henan Province, Nanyang Normal University, Nanyang, PR China.
Lunguang YaoHenan Province Engineering Technology Research Center of Animal Disease Diagnosis and Integrated Control, Henan Key Laboratory of Insect Biology, Henan Province Engineering Research Center of Insect Bioreactor, China-UK International Joint Laboratory for Insect Biology of Henan Province, Nanyang Normal University, Nanyang, PR China.
Zhijun TianState Key Laboratory for Animal Disease Control and Prevention, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, PR China.
Chaoliang LengHenan Province Engineering Technology Research Center of Animal Disease Diagnosis and Integrated Control, Henan Key Laboratory of Insect Biology, Henan Province Engineering Research Center of Insect Bioreactor, China-UK International Joint Laboratory for Insect Biology of Henan Province, Nanyang Normal University, Nanyang, PR China. lenghan1223@126.com.

Funding

the Natural Science Foundation of Henan Province, China 242300421335The Scientific and Technological Project of Henan Province 252102111005
6 · The paper itself

Abstract

backgroundPorcine circovirus type 3 (PCV3) is an emerging pathogen with high genetic variability, posing a continuous challenge to swine health and disease control. Ongoing viral evolution highlights the need for molecular surveillance to monitor circulating PCV3 strains.

resultsFrom 2023 to 2024, 257 blood and tissue samples from pigs with reproductive and respiratory disorders were collected in Henan Province, China. PCV3 was detected in 21.79% (56/257) of samples by quantitative real-time PCR (qPCR). Genetic characterization of 15 new PCV3 strains showed 98.95-99.95% nucleotide (nt) identity among themselves and 98.70-99.85% identity with global reference strains. Phylogenetic analysis of the ORF2 genes identified PCV3a-1, PCV3a-2, PCV3a-IM, PCV3b, and PCV3c subtypes, with PCV3b predominating. Notably, a genetically divergent strain, HN240609, clustered within the PCV3c subgroup. Additionally, multiple unique amino acid (aa) mutations were observed in the predicted T-cell and B-cell epitope regions of the capsid (Cap) protein (R10K, A35V, T102A, T102S, F104Y, T170A, and V180I).

conclusionsGenetically diverse PCV3 strains are co-circulating in Henan Province, and mutations in antigenic regions of the Cap protein may facilitate immune evasion. Continuous molecular surveillance is therefore essential for effective PCV3 prevention and control.

Indexed as

Circoviridae InfectionsCircovirusGenetic VariationSwine DiseasesAnimalsCapsid ProteinsChinaPhylogenySwineCapsid ProteinsGenetic variationPCV3cPhylogenetic analysisPorcine circovirus type 3

Identifiers

PMID42151946
PMCPMC13360887

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.