ArticleBMC pulmonary medicine2026
Radiologists' diagnostic confidence in surgically referred pulmonary nodules: a routine computed tomography report retrospective analysis.
Article in BMC pulmonary medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundImaging plays a critical role in the preoperative evaluation of pulmonary nodules, especially when obtaining a definitive biopsy is not feasible. This study evaluated the reliability of routine computed tomography (CT) reports in differentiating benign from malignant nodules and to identify imaging features that influenced radiologists' diagnostic confidence.
methodsWe retrospectively analyzed 823 patients who underwent preoperative CT for pulmonary nodules at a single institution between 2017 and 2023. Radiologists' diagnostic confidence levels, recorded on a five-point scale (1 = benign, 5 = malignant), were extracted from reports and compared with pathological diagnoses. Diagnostic performance was assessed using the area under the curve (AUC) and risk of malignancy (ROM).
resultsA total of 823 pulmonary lesions were evaluated, including 701 malignant and 122 benign nodules. Radiologists' interpretations demonstrated excellent diagnostic performance, with an AUC of 0.961; 95%CI: 0.94-0.98, sensitivity of 0.95, and specificity of 0.86. Notably, 99.4% of nodules rated "5" were confirmed malignant. Diagnostic accuracy was significantly higher for ground-glass nodules compared with solid nodules (AUC 0.995 vs. 0.938, p < 0.001) and when prior CT scans were available (AUC 0.983 vs. 0.951, p = 0.036). The presence of coexisting chronic obstructive pulmonary disease or interstitial lung disease modestly reduced accuracy (AUC 0.973 vs. 0.919, p = 0.089).
conclusionRadiologists' diagnostic confidence levels recorded in routine preoperative CT reports demonstrated high concordance with pathological outcomes in pulmonary nodules referred for diagnostic surgical resection after nondiagnostic biopsy, suggesting that clinical decision-making in this highly selected population is generally reliable.
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