Regression of central sensitization after bilateral focused ultrasound medial thalamotomies in atypical orofacial pain? - a case report.

Matus Velicky Buecheler, Lukasz Kolakowski, Marie Therese Kleinsorge, Heiko Pohl, Lennart Stieglitz, Susanne Wegener

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In one paragraph

Article in BMC neurology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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6 authors.

Matus Velicky BuechelerDepartment of Neurology, University Hospital Zurich, Frauenklinikstrasse 26, Zurich, 8091, Switzerland. matus.velickybuecheler@usz.ch.

Lukasz KolakowskiDepartment of Neurology, University Hospital Zurich, Frauenklinikstrasse 26, Zurich, 8091, Switzerland.

Marie Therese KleinsorgeDepartment of Neurology, University Hospital Zurich, Frauenklinikstrasse 26, Zurich, 8091, Switzerland.

Heiko PohlDepartment of Neurology, University Hospital Zurich, Frauenklinikstrasse 26, Zurich, 8091, Switzerland.

Lennart StieglitzDepartment of Neurosurgery, University Hospital Zurich, Zurich, Switzerland.

Susanne WegenerDepartment of Neurology, University Hospital Zurich, Frauenklinikstrasse 26, Zurich, 8091, Switzerland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Orofacial pain syndromes are a heterogenous group of pain disorders resulting in substantial morbidity. They are often refractory to medical treatment and can have an enormous impact on quality of life. Central sensitization plays a major role in chronic pain disorders and poses a diagnostic and therapeutic challenge. Transcranial magnetic resonance-guided focused ultrasound bilateral medial thalamotomy is an emerging treatment in chronic pain syndromes with central sensitization. We here describe a 76-year-old female patient with a long history of atypical orofacial pain and central sensitization with a significant, but temporary regression of the latter after medial thalamotomy using bilateral focused ultrasound.

Indexed as

Central Nervous System SensitizationFacial PainThalamusAgedFemaleHumansCentral lateral thalamotomyCentral sensitizationFocused ultrasoundOrofacial pain

Identifiers

PMID42151860

DOI10.1186/s12883-026-04966-7

PMCPMC13348938

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