Trial reportBMC anesthesiology2026
Pericapsular nerve group (PENG) block at 10 mL vs. 20 mL for postoperative analgesia after total hip arthroplasty: a randomized controlled trial.
Trial report in BMC anesthesiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06166602 (Comparison of the Impacts of Ultrasound-guided Pericapsular Nerve Group), which is not on this map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Comparison of the Impacts of Ultrasound-guided Pericapsular Nerve Group (PENG) Block Applied in Different Volumes on Postoperative Pain in Hip Replacement Surgeries: A Randomized Clinical Trial
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe pericapsular nerve group (PENG) block is increasingly used for analgesia in hip-related procedures. However, the optimal local anesthetic volume remains unclear. This randomized non-inferiority trial aimed to compare the analgesic efficacy of 10 mL versus 20 mL PENG block after total hip arthroplasty, hypothesizing that the lower volume would provide non-inferior analgesia.
methodsIn this single-center randomized controlled non-inferiority trial, 50 patients undergoing hip replacement surgery received an ultrasound-guided PENG block with 0.25% bupivacaine, either 20 mL (n = 25) or 10 mL (n = 25). Postoperative analgesia was provided using morphine patient-controlled analgesia. Pain scores at rest and during movement were assessed at predefined time points up to 24 h postoperatively. The primary outcome was the NRS pain score at rest 1 h after surgery. Secondary outcomes included opioid consumption, quadriceps muscle strength, postoperative nausea and vomiting, and patient satisfaction.
resultsThere were no significant differences between groups in opioid-related side effects, quadriceps muscle weakness, patient satisfaction, or length of hospital stay. Non-inferiority analysis demonstrated that the median differences in NRS scores between groups remained within the predefined non-inferiority margin of 1 NRS point at all assessment time points. Non-inferiority of the 10 mL PENG block was confirmed for the primary outcome.
conclusionsA 10 mL PENG block provides postoperative analgesia non-inferior to a 20 mL volume without increasing opioid consumption or motor weakness, suggesting that lower volumes may be sufficient and potentially safer after total hip arthroplasty.
trial registrationClinicalTrials.gov, NCT06166602. Registered on December 04, 2023. Retrospectively registered (study start date July 30, 2023).
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