ArticleBMC microbiology2026
Characterization of multidrug-resistant ST363-KL151 Klebsiella variicola clinical isolates harboring bla
Article in BMC microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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6 authors.
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Abstract
backgroundKlebsiella variicola is an emerging multidrug‑resistant opportunistic pathogen that is often misidentified as K. pneumoniae in clinical laboratories. Here, we investigated four NDM‑9-producing K. variicola ST363‑KL151 isolates from patients treated at a tertiary-care centre in China.
methodsWhole-genome sequencing and genomic analyses were performed to confirm species identity, define molecular characteristics, and identify resistance determinants. Core-genome SNP analysis was used to assess phylogenetic relatedness to international strains. Carbapenem-resistance transferability was evaluated by conjugation to E. coli. Biofilm formation, epithelial-cell invasion/cytotoxicity, serum bactericidal resistance, and virulence in a Galleria mellonella infection model were assessed.
resultsAntimicrobial susceptibility testing revealed a broad resistance profile encompassing β‑lactams (including carbapenems), aminoglycosides, fluoroquinolones, and fosfomycin, while retaining susceptibility to tigecycline. One isolate demonstrated elevated polymyxin resistance with an MIC of 64 mg/L, mediated by mgrB truncation (p.Gln30*). Whole‑genome sequencing identified a IncHI2A plasmid carrying a unique IS26‑flanked bla
conclusionsThese findings identify NDM‑9‑producing K. variicola ST363‑KL151 as a multidrug‑resistant lineage, emphasizing the need for accurate species identification and genome‑based surveillance to prevent its further clinical spread.
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