Evidence map›Paper›PMID 42151744›Full record

Trial reportAlzheimer's & dementia : the journal of the Alzheimer's Association2026

Changes in arterial stiffness under blood pressure control are independently associated with cognitive impairment: The Systolic Blood Pressure Intervention Trial (SPRINT).

Timothy M Hughes, Byron C Jaeger, Sarah A Gaussoin, Ryan Pewowaruk, Theodore DeConne, Adam D Gepner, Cecila Peterson, David M Reboussin, Jeff Williamson, Mark A Supiano

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Timothy M HughesDepartment of Internal Medicine, Section on Gerontology and Geriatric Medicine and the Sticht Center for Healthy Aging and Alzheimer's Prevention, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.
Byron C JaegerDepartment of Biostatistics and Data Science, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.
Sarah A GaussoinDepartment of Biostatistics and Data Science, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.
Ryan PewowarukRyan Pewowaruk Research Consulting, Madison, Wisconsin, USA.
Theodore DeConneDepartment of Internal Medicine, Section on Gerontology and Geriatric Medicine and the Sticht Center for Healthy Aging and Alzheimer's Prevention, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.
Adam D GepnerDepartment of Medicine-Division of Cardiovascular Medicine, William S. Middleton Memorial Veteran's Hospital, Madison, Wisconsin, USA.
Cecila PetersonGeriatrics Division, Spencer Fox Eccles School of Medicine and Center on Aging, University of Utah, Salt Lake City, Utah, USA.
David M ReboussinDepartment of Biostatistics and Data Science, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.
Jeff WilliamsonDepartment of Internal Medicine, Section on Gerontology and Geriatric Medicine and the Sticht Center for Healthy Aging and Alzheimer's Prevention, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.
Mark A SupianoGeriatrics Division, Spencer Fox Eccles School of Medicine and Center on Aging, University of Utah, Salt Lake City, Utah, USA.

Funding

INSTITUTIONAL CLINICAL AND TRANSLATIONAL SCIENCE AWARDUL1RR024134 · NCRR · UNIVERSITY OF PENNSYLVANIA · PI FITZGERALD, GARRET A · 2006 to 2011
$70.4M
University of Pittsburgh Clinical and Translational Science InstituteUL1TR000005 · NCATS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI REIS, STEVEN E · 2012 to 2015
$50.8M
Clinical and Translational Science Collaborative of ClevelandUL1TR000439 · NCATS · CASE WESTERN RESERVE UNIVERSITY · PI KONSTAN, MICHAEL W. · 2012 to 2016
$50.0M
The Vanderbilt Institute for Clinical and Translational Research (VICTR)UL1TR000445 · NCATS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BERNARD, GORDON RAPHAEL · 2012 to 2016
$41.4M
Institutional Clinical and Translational Science AwardUL1TR000003 · NCATS · UNIVERSITY OF PENNSYLVANIA · PI FITZGERALD, GARRET A · 2012 to 2015
$38.9M
Wake Forest Clinical and Translational Science AwardUL1TR001420 · NCATS · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI ARD, JAMY D, FOLEY, KRISTIE L · 2015 to 2023
$32.3M
Tufts Clinical and Translational Research InstituteUL1TR001064 · NCATS · TUFTS UNIVERSITY BOSTON · PI SELKER, HARRY P. · 2013 to 2017
$26.4M
University of Iowa Clinical and Translational Science Program (TL1)UL1RR025755 · NCRR · OHIO STATE UNIVERSITY · PI JACKSON, REBECCA D · 2008 to 2011
$26.3M
Wake Forest University School of Medicine Alzheimer's Disease Research CenterP30AG072947 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI SUZANNE CRAFT · 2021 to 2026
$24.3M
CTSA INFRASTRUCTURE FOR PEDIATRIC RESEARCHUL1RR025771 · NCRR · BOSTON UNIVERSITY MEDICAL CAMPUS · PI CENTER, DAVID M. · 2008 to 2011
$17.6M
TUFTS CLINICAL AND TRANSLATION SCIENCE INSTITUTE (UL1): BPCAUL1RR025752 · NCRR · TUFTS UNIVERSITY BOSTON · PI SELKER, HARRY P. · 2008 to 2011
$17.6M
Clinical and Translational Science Institute at Children's NationalUL1TR000075 · NCATS · CHILDREN'S RESEARCH INSTITUTE · PI GUAY-WOODFORD, LISA MARIE · 2012 to 2015
$13.7M
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)NCATS NIH HHS UL1 TR000002NCATS NIH HHS UL1 TR000003NCATS NIH HHS UL1 TR000005NCATS NIH HHS UL1 TR000050NCATS NIH HHS UL1 TR000064NCATS NIH HHS UL1 TR000073NCATS NIH HHS UL1 TR000075NCATS NIH HHS UL1 TR000093NCATS NIH HHS UL1 TR000105NCATS NIH HHS UL1 TR000439NCATS NIH HHS UL1 TR000445NCATS NIH HHS UL1 TR001064NCATS NIH HHS UL1 TR001420NCRR NIH HHS UL1 RR024134NCRR NIH HHS UL1 RR025752NCRR NIH HHS UL1 RR025755NCRR NIH HHS UL1 RR025771NHLBI NIH HHS HHSN268200900040CNHLBI NIH HHS HHSN268200900046CNHLBI NIH HHS HHSN268200900047CNHLBI NIH HHS HHSN268200900048CNHLBI NIH HHS HHSN268200900049CNHLBI NIH HHS R01 HL107241NHLBI NIH HHS R01 HL107257NIA NIH HHS P30 AG072947NIGMS NIH HHS P30 GM103337NIH HHSNINDS NIH HHS
6 · The paper itself

Abstract

backgroundEffects of blood pressure (BP) control on the relationships between arterial stiffness and subsequent cognitive impairment remain unclear.

methodsThe Systolic Blood Pressure Intervention Trial Pulse Wave Velocity (PWV) substudy evaluated the effect BP control on total (T-PWV, in m/s), structural (S-PWV), and load-dependent (LD-PWV) arterial stiffness over 3 years as they related to time to cognitive impairment over 10 years modeled using multivariable proportional hazard models for baseline stiffness and joint longitudinal survival models for changes in stiffness.

resultsSix hundred fourteen participants with stiffness measures had 90 cognitive impairment events over follow-up. Reductions in LD-PWV under intensive BP control were associated with 21% risk reduction for cognitive impairment. T-PWV and S-PWV continued to increase regardless of BP control with each m/s increase in stiffness associated with 11% to 12% increase in risk for cognitive impairment. DISCUSSION: Intensive SBP control reduced LD-PWV over 3 years, which reduced the risk of cognitive impairment over 10 years of follow-up.

Indexed as

Antihypertensive AgentsBlood PressureCognitive DysfunctionHypertensionVascular StiffnessAgedFemaleHumansMaleProportional Hazards ModelsPulse Wave AnalysisAntihypertensive Agentsarterial stiffnessblood pressureclinical trialcognitive impairmentdementia

Identifiers

PMID42151744
PMCPMC13183588

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.