Evidence map›Paper›PMID 42151716›Full record

ReviewHigh blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension2026

Natriuretic Peptides as a Biomarker of Cognitive Decline in Hypertension.

Giovanna Gallo, Gianmarco Dutti, Maurizio Volterrani, Massimo Fini, Giuliano Tocci, Massimo Volpe

Abstract readReview
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In one paragraph

Review in High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

6 authors.

Giovanna GalloDepartment of Clinical and Molecular Medicine, Sapienza University of Rome, Via di Grottarossa, Rome, 1035-1039, 00189, Italy.
Gianmarco DuttiDepartment of Clinical and Molecular Medicine, Sapienza University of Rome, Via di Grottarossa, Rome, 1035-1039, 00189, Italy.
Maurizio VolterraniIRCCS San Raffaele, Via della Pisana 235, Rome, 00163, Italy.
Massimo FiniIRCCS San Raffaele, Via della Pisana 235, Rome, 00163, Italy.
Giuliano TocciDepartment of Clinical and Molecular Medicine, Sapienza University of Rome, Via di Grottarossa, Rome, 1035-1039, 00189, Italy.
Massimo VolpeDepartment of Clinical and Molecular Medicine, Sapienza University of Rome, Via di Grottarossa, Rome, 1035-1039, 00189, Italy. massimo.volpe@uniroma1.it.ORCID http://orcid.org/0000-0002-9642-8380

Funding

Ministero della Salute Ricerca Corrente
6 · The paper itself

Abstract

Cognitive decline and dementia are frequent consequences of atherosclerosis and hypertension.Indeed, recent guidelines have identified cognitive decline as a major consequence of high blood pressure and one of the therapeutic targets in hypertension. Unfortunately, early assessment of cognitive decline in the clinical practice is often difficult due to the heterogeneity and the variable severity of the clinical presentations and manifestations.It would be of great help to rely on reproducible clinical markers that can herald the early onset of cognitive decline and can help in assessing the severity or guiding management on the basis of the response to treatment. In such a context, a link between natriuretic peptides (NPs), cognitive function and hypertension has been reported.The aim of this article is to analyse and update the available evidence in support of NPs as a potential biomarker of cognitive decline with regard to the context of hypertension and to identify potential future clinical diagnostic and therapeutic applications.

Indexed as

Blood PressureCognitionCognitive DysfunctionHypertensionNatriuretic PeptidesAnimalsBiomarkersHumansPredictive Value of TestsPrognosisRisk FactorsBiomarkersNatriuretic PeptidesCognitive declineDementiaHypertensionHypertension mediated organ damageNatriuretic peptidesRehabilitation

Identifiers

PMID42151716

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.