Evidence map›Paper›PMID 42151683›Full record

ArticleMethods in molecular biology (Clifton, N.J.)2026

3D Bioprinted Tumor Constructs for Photothermal Therapy: Emerging Opportunities in Microgravity Research.

Maria Laura Sforza, Maila Chirivì, Claudia Bearzi, Giovanni Perotto, Paolo Rosa, Francesca Petronella, Roberto Rizzi, Luciano De Sio

Abstract read
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In one paragraph

Article in Methods in molecular biology (Clifton, N.J.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Maria Laura SforzaDepartment of Medical-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Corso della Repubblica 79, 04100,, Latina, Italy.
Maila ChirivìDepartment of Molecular Medicine, Sapienza University, Viale Regina Elena, 324, 00161,, Rome, Italy.
Claudia BearziInstitute for Biomedical Technologies, National Research Council (ITB-CNR), Segrate, 20090,, Milan, Italy.
Giovanni PerottoSmart Materials, Istituto Italiano di Tecnologia, Via Morego 30, 16163,, Genoa, Italy.
Paolo RosaDepartment of Medical-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Corso della Repubblica 79, 04100,, Latina, Italy.
Francesca PetronellaInstitute of Crystallography, National Research Council, (CNR-IC), Via Salaria Km 29, 300, Monterotondo, 00015,, Rome, Italy.
Roberto RizziDepartment of Medical-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Corso della Repubblica 79, 04100,, Latina, Italy.
Luciano De SioDepartment of Medical-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Corso della Repubblica 79, 04100,, Latina, Italy. luciano.desio@uniroma1.it.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Thanks to advancements in innovative technologies, it is now possible to conduct testing for new drugs and medical treatments without using animals. This significant development not only saves time and costs but also eliminates the need for animal sacrifice. In this context, we present a 3D-printed construct made from glioblastoma U87-MG cells combined with biomimetic keratin-coated gold nanoparticles (Ker-AuNPs). By utilizing the thermoplasmonic properties of these Ker-AuNPs, we can test photothermal therapy (PTT)-a minimally invasive treatment designed to destroy cancer cells-using a more realistic representation of the tumor environment. Additionally, our research represents a significant turning point for potential applications in microgravity conditions, enabling us to speculate on the efficacy of PTT in a controlled gravity environment.

Indexed as

BioprintingGlioblastomaPhotothermal TherapyPrinting, Three-DimensionalCell Line, TumorGoldHumansKeratinsMetal NanoparticlesWeightlessnessGoldKeratins3D modelBiomimicryBioprintingCancerGlioblastomaGold nanoparticlesHuman tissuesOpticsPhoto-thermal therapyPlasmonics

Identifiers

PMID42151683

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.