Harnessing Organocatalysis for Enantioselective Chromane Synthesis.

Vipin K Maikhuri, Divya Mathur, Pooja Saluja, Ankita Chaudhary, Smriti Srivastava

Abstract readReview

In one paragraph

Review in Topics in current chemistry (Cham), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

Visible light promoted chalcone transformations and their prominence for the synthesis of functionalized molecules: a review.Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology · 2026
Review

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Vipin K MaikhuriDepartment of Chemistry, University of Delhi, Delhi, 110007, India.

Divya MathurDepartment of Chemistry, University of Delhi, Delhi, 110007, India. divyamathur@dr.du.ac.in.

Pooja SalujaDepartment of Chemistry, Maitreyi College, University of Delhi, Delhi, 110021, India.

Ankita ChaudharyDepartment of Chemistry, Maitreyi College, University of Delhi, Delhi, 110021, India.

Smriti SrivastavaDrug Discovery Program, Ontario Institute for Cancer Research, Toronto, ON, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chromanes are privileged scaffolds in medicinal chemistry because they exhibit diverse biological activities. Their stereoselective synthesis has become a critical objective in drug development. The emergence of organocatalysis has sparked a paradigm shift in synthetic chemistry by offering a highly selective alternative to traditional metal-catalyzed reactions. This review discusses the transformative impact of organocatalyzed reactions on the asymmetric synthesis of chromane derivatives, focusing on key classes of catalysts such as chiral phosphoric acid, chiral amines, bifunctional systems, and others reported since 2020. Organocatalysis not only achieves high levels of stereocontrol but also adheres to the principles of green chemistry by eliminating toxic metals and enabling mild reaction conditions. These advancements diversify synthetic methodologies and establish organocatalysis as a fundamental approach in the sustainable synthesis of bioactive chromanes.

Indexed as

ChromansAminesCatalysisMolecular StructurePhosphoric AcidsStereoisomerismAminesChromansphosphoric acidPhosphoric AcidsAsymmetric synthesisChromaneEnantioselective synthesisO-HeterocyclesOrganocatalysisStereochemistry

Identifiers

PMID42151657

DOI10.1039/C3OB42100G

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