ArticleJournal of neuro-oncology2026
Laser interstitial thermal therapy versus stereotactic radiosurgery for first-time treatment of recurrent glioblastoma: a retrospective single-center study.
Article in Journal of neuro-oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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4 authors.
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Abstract
backgroundDespite multimodal therapy, glioblastomas invariably recur. In focal recurrent glioblastoma IDH-wildtype (rGBM), local therapy options include laser interstitial thermal therapy (LITT) and stereotactic radiosurgery (SRS), but their relative utilities are unknown. The goal of this study is to compare the efficacy of these two treatment modalities in a homogeneous rGBM population.
methodsWe conducted a retrospective study of patients undergoing surgical procedures for rGBM between 2010 and 2025. All patients underwent either LITT or SRS at first recurrence. Survival outcomes were assessed with univariable log-rank tests and multivariate Cox regression models. A propensity-score matching (PSM) was performed to address confounders.
results57 patients were identified; of these, 10 underwent LITT, and 47 underwent SRS. There was no difference in post-recurrence survival (PRS) between groups (11.5 months vs. 13.4 months, p = 0.824). There were no surgical complications in the LITT cohort. In the SRS cohort, there were two symptomatic radiation necrosis cases (0% vs. 4.3%, p = 1.000). Contrast-enhancing tumor volume at recurrence was larger in the LITT cohort (8.49 cm
conclusionWithin the limitations of a relatively small sample size, no statistically significant differences in outcomes were observed between LITT and SRS for the treatment of small, focal rGBM. Both modalities remain viable salvage options for small focal rGBM. Larger, multi-institutional studies are warranted.
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