Evidence map›Paper›PMID 42151626›Full record

ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2026

Altered amygdala structural connectivity and relations to social cognition in frontotemporal dementia.

Mengjie Huang, Marshall A Dalton, Sophie Matis, Her Ai Claris Teng, Sau Chi Cheung, Yun T Hwang, Rebekah M Ahmed, Ramon Landin-Romero, Olivier Piguet

Abstract read
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In one paragraph

Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

9 authors.

Mengjie HuangBrain and Mind Centre, The University of Sydney, Camperdown, New South Wales, Australia.ORCID https://orcid.org/0000-0002-7684-4221
Marshall A DaltonBrain and Mind Centre, The University of Sydney, Camperdown, New South Wales, Australia.
Sophie MatisBrain and Mind Centre, The University of Sydney, Camperdown, New South Wales, Australia.
Her Ai Claris TengBrain and Mind Centre, The University of Sydney, Camperdown, New South Wales, Australia.
Sau Chi CheungBrain and Mind Centre, The University of Sydney, Camperdown, New South Wales, Australia.
Yun T HwangBrain and Mind Centre, The University of Sydney, Camperdown, New South Wales, Australia.
Rebekah M AhmedBrain and Mind Centre, The University of Sydney, Camperdown, New South Wales, Australia.
Ramon Landin-RomeroBrain and Mind Centre, The University of Sydney, Camperdown, New South Wales, Australia.
Olivier PiguetBrain and Mind Centre, The University of Sydney, Camperdown, New South Wales, Australia.

Funding

ARC Discovery Project DP210102378Australian Government Research Training Program (RTP) scholarshipNational Health and Medical Research Council GNT1037746NHMRC Investigator GNT2008020NHMRC Investigator GNT2010064NHMRC Postgraduate Scholarship GNT2050196The Australian Research Council Centre of Excellence in Cognition and Its Disorders CE11000102
6 · The paper itself

Abstract

introductionThe amygdala is critical for social cognition and undergoes profound damage in frontotemporal dementia (FTD). While its atrophy is well documented, changes in its structural connectivity and their behavioral relevance remain unclear.

methodsUsing fixel-based analysis and tractography, we examined amygdala connectivity in patients with behavioral variant FTD (bvFTD; n = 21), semantic dementia (SD; n = 19), progressive non-fluent aphasia (PNFA; n = 18), and 28 controls. Associations with empathy and emotion recognition were explored using partial correlations.

resultsBvFTD and SD showed marked degeneration of amygdala-associated tracts, while PNFA exhibited subtle left temporal changes. Tractography revealed reduced amygdala connectivity with regions supporting memory, visual, language, semantic, and motor functions, to varying degrees across subtypes. Social cognitive deficits were correlated with amygdala-cerebellum connectivity in bvFTD and with amygdala-hippocampus connectivity in SD. DISCUSSION: These findings were the first to demonstrate subtype-specific patterns of amygdala white matter alteration and their relevance to social cognitive symptoms in FTD.

Indexed as

AmygdalaFrontotemporal DementiaSocial CognitionAgedDiffusion Tensor ImagingEmotionsFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedNeural PathwaysNeuropsychological TestsPrimary Progressive Nonfluent Aphasiaamygdaladiffusion magnetic resonance imagingfixel‐based analysisfrontotemporal dementiasocial cognitiontractography

Identifiers

PMID42151626
PMCPMC13183591

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.