Exploring the relationship between oxidative balance score and sex hormone levels in American males: a cross-sectional study.

Kai Tao, Wei Zhang, Weichao Huang, Guofa Lu, Hang Xu, Shi Qiu, Lu Yang

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Article in Hormones (Athens, Greece), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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7 authors.

Kai Tao *Department of Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu, 610041, China.

Wei Zhang *Department of Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu, 610041, China.

Weichao Huang *Department of Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu, 610041, China.

Guofa LuDepartment of Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu, 610041, China.

Hang XuDepartment of Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu, 610041, China.

Shi QiuDepartment of Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu, 610041, China. qiushi@scu.edu.cn.

Lu YangDepartment of Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu, 610041, China. wycleflue@scu.edu.cn.

Funding

China Postdoctoral Science Foundation 2020M670057ZXNational Key Research and Development Program of China 2022YFC3602901, 2022YFC3602902National Nature Science Foundation of China 82372831Post-doctoral Science Research Foundation of Sichuan University 2020SCU12041Programs from Science and Technology Department of Sichuan Province 2023NSFSC1906, 2021YJ0462the Postdoctoral Fellowship Program of CPSF under Grant Number GZB20240491

6 · The paper itself

Abstract

purposeThe oxidative balance score (OBS) was developed to reflect the overall exposure of the body to antioxidants and pro-oxidants in the individual's lifestyle and diet. The research aims to explore the relationship between OBS and sex hormones, including total testosterone (TT) and estradiol (E2), as well as indices including sex hormone-binding globulin (SHBG), testosterone deficiency (TD), free testosterone, and the ratio of TT to E2.

methodsA total of 2464 male participants were enrolled in the study during the period 2013 to 2016. Multivariable regression analyses were performed to investigate the association between OBS and sex hormones. Stratified analysis was conducted in participants of different age, body mass index (BMI), poverty income ratio, smoking status, alcohol consumption, and diabetes mellitus (DM).

resultsWe found that OBS (β = 2.13, 95% CI: 0.17 ~ 4.09, P = 0.030) and lifestyle OBS (β = 21.09, 95% CI: 9.27 ~ 32.90, P = 0.004) were significantly correlated with TT with full adjustment. We also found noteworthy relationships between lifestyle OBS and SHBG (β = 2.55, 95% CI: 0.77 ~ 4.33, P = 0.010), TD (OR = 0.76, 95% CI: 0.58 ~ 1.00, P = 0.045), and ratio of TT to E2 (β = 1.10, 95% CI: 0.71 ~ 1.50, P < 0.001). Stratified analyses by many covariates revealed that the results were basically stable across populations.

conclusionThe results showed that males who lead an antioxidant-rich lifestyle had increased serum TT levels and were less likely to develop TD. This suggests that antioxidant-rich lifestyle choices may additionally help to prevent disorders related to sex hormone imbalance.

Indexed as

AntioxidantsEstradiolLife StyleOxidative StressSex Hormone-Binding GlobulinTestosteroneAdultAgedCross-Sectional StudiesHumansMaleMiddle AgedUnited StatesAntioxidantsEstradiolSex Hormone-Binding GlobulinTestosteroneAntioxidantOxidative balance scoreSex steroid hormonesTestosteroneTestosterone deficiency

Identifiers

PMID42151602

DOI10.1207/s15327914nc382_4

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.