ArticleAnnals of hematology2026
Zanubrutinib potentiates polatuzumab vedotin efficacy in DLBCL with concurrent CD79b upregulation.
Article in Annals of hematology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
In diffuse large B-cell lymphoma (DLBCL), although most patients are curable, the approximately one-third who experience refractory or relapsed disease face a poor prognosis, underscoring the need for novel therapeutic strategies. Although Bruton's tyrosine kinase inhibitors (BTKis) exhibit anti-lymphoma activity in various B-cell malignancies, they are less effective in patients with the germinal center B-cell-like (GCB) subtype. The anti-CD79b antibody-drug conjugate polatuzumab vedotin has been approved for DLBCL treatment. Previous studies have shown that the combination of the second-generation BTKi zanubrutinib and polatuzumab vedotin, within the R-CHOP regimen, yielded higher response rates in preliminary clinical studies; however, the efficacy of this combination remains unclear. This study aimed to evaluate whether zanubrutinib plus polatuzumab vedotin could represent a novel therapeutic approach. Through assays of drug combination, cell proliferation, cell cycle, and apoptosis, we demonstrated that this combination synergistically inhibited DLBCL cell proliferation both in vitro and in vivo. Moreover, zanubrutinib enhanced polatuzumab vedotin-induced G
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