ArticleInflammation research : official journal of the European Histamine Research Society ... [et al.]2026
Single-cell and spatial transcriptomics reveal an arachidonic acid-related cellular atlas in lung adenocarcinoma.
Article in Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
purposeArachidonic acid (AA), a membrane-abundant polyunsaturated fatty acid, is primarily liberated from membrane phospholipids by phospholipase A PATIENTS AND
methodsScRNA-seq and ST-seq data underwent quality control, integration, clustering, and annotation. Cellular communication analysis explored TME cell/regional regulatory links. Differential cell populations were identified between primary tumor and normal groups; key cells were selected via enrichment pathways and communication patterns. Biomarkers were chosen through differential expression analysis and protein-protein interaction (PPI) network, followed by enrichment analysis, molecular/drug network construction, key cell re-clustering, and pseudotime analysis.
resultsTwelve cell types were identified in scRNA-seq, with T cells and epithelial cells among the top three. ST-seq revealed LUAD tissues comprise cancer, lymph, normal epithelium, and stroma regions. T cells and epithelial cells had extensive intercellular connections, designated as key cells. PTGS2, TBXAS1, AKR1C3, and HPGD were selected as biomarkers via PPI network. Re-clustering and pseudotime analysis showed most LUAD epithelial cells and T cells were terminally differentiated; PTGS2 and HPGD expression rose then declined in the middle-late stages of epithelial cell subpopulation differentiation.
conclusionIn this study, we observed the crucial functions of T cells and epithelial cells as well as AA-related biomarkers PTGS2, TBXAS1, AKR1C3, and HPGD in LUAD. These findings provide mechanistic context and suggest testable biomarkers for future translational studies.
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