ArticleAnalytical and bioanalytical chemistry2026
Exploring a direct-lock NIR light-controlled strategy under APE1 gating: toward high-fidelity aptasensing in living biosamples via a sensitive auto-reinforcing iterative cascaded DNA nanobooster.
Article in Analytical and bioanalytical chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Developing a DNA nanobooster-constructed aptasensing platform that enables high-fidelity imaging in living biosamples is of importance for detecting disease-correlated marker molecules. Here, we explore a direct-lock near-infrared (NIR) light-controlled strategy under apurinic/apyrimidinic endonuclease 1 (APE1) gating, which is then incorporated with a sensitive auto-reinforcing iterative cascaded DNA nanobooster. In one respect, the sensing system gains forceful bio-targeting proficiency by applying endogenous APE1 in biological media as a sensor gating, followed by implementing a direct-lock NIR light-controlled strategy through the combination of ultraviolet-emitting upconversion nanoparticles and a 7-(Diethylamino)coumarin-4-ylmethyl-group linkage at the apurinic/apyrimidinic site of one DNA strand. In the other aspect, a first-stage hybridization chain reaction (HCR) amplification and a later-stage iterative HCR cycle amplification triggered by a self-propelled Mn
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