Evidence map›Paper›PMID 42151464›Full record

ArticleSurgical endoscopy2026

Nomogram for preoperative prediction of lymph node metastasis in patients with early submucosal right-sided colon cancer: a dual-center retrospective cohort study.

Fei Han, Yuling Liu, Yaning Wang, Jie Wang, Weiming Xiao, Xue Dong, Xiaolei Shi, Yanbing Ding

Abstract readMulticenter Study
PubMed Publisher
In one paragraph

Article in Surgical endoscopy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Fei Han *The Affiliated Hospital of Yangzhou University, Yangzhou University, Yangzhou, 225000, Jiangsu, China.
Yuling Liu *Yancheng Third People's Hospital, Yancheng, 224008, Jiangsu, China.
Yaning Wang *The Affiliated Hospital of Yangzhou University, Yangzhou University, Yangzhou, 225000, Jiangsu, China.
Jie WangYangzhou University, Yangzhou, 225000, China.
Weiming XiaoThe Affiliated Hospital of Yangzhou University, Yangzhou University, Yangzhou, 225000, Jiangsu, China.
Xue DongThe First Affiliated Hospital of China Medical University, Shenyang, China.
Xiaolei ShiThe Affiliated Hospital of Yangzhou University, Yangzhou University, Yangzhou, 225000, Jiangsu, China.
Yanbing DingThe Affiliated Hospital of Yangzhou University, Yangzhou University, Yangzhou, 225000, Jiangsu, China. ybding@yzu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPreoperative lymph node metastasis (LNM) risk stratification is crucial for selecting endoscopic resection or colectomy in T1 right-sided colon cancer (T1 RCC), yet validated tools integrating preoperative predictive indicators remain lacking.

methodsThis retrospective study included 628 patients with T1 RCC. Single-predictor and multi-predictor logistic regression models identified independent preoperative predictors of LNM to construct a nomogram. Model performance was assessed using area under the curve (AUC) and calibration metrics.

resultsSix preoperative factors constituted independent predictors of LNM: age (OR = 0.92, 95% CI: 0.88-0.97), tumor location (hepatic flexure: OR = 3.50, 95% CI: 1.68-7.31), poorly differentiated tumor (OR = 4.21, 95% CI: 2.23-7.94), CT-detected lymphadenopathy (OR = 5.14, 95% CI: 2.79-9.46), elevated CEA (OR = 3.26, 95% CI: 1.77-6.01), and elevated CA 19-9 (OR = 1.98, 95% CI: 1.04-3.77). This predictive model demonstrated high discriminatory ability: 0.84 AUC in training preserved at 0.83 upon validation. Calibration curves demonstrated optimal agreement with observed outcomes, supported by a non-significant Hosmer-Lemeshow test. Decision curve analysis further established robust clinical net benefit across threshold probabilities.

conclusionThis preoperative predictive model accurately quantifies the risk of LNM in T1 RCC using routine parameters, guiding individualized treatment decisions and preventing unnecessary colectomy in low-risk patients.

Indexed as

Colonic NeoplasmsLymphatic MetastasisNomogramsAgedColectomyFemaleHumansMaleMiddle AgedRetrospective StudiesRisk AssessmentEarly right-sided colon cancerLymph node metastasisNomogramRisk factorsSubmucosa

Identifiers

PMID42151464

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.