Evidence map›Paper›PMID 42151442›Full record

ArticleMolecular psychiatry2026

MSK1 mediates BDNF-dependent MeCP2-S421 phosphorylation in postnatal striatal development and psychiatric-relevant behaviours.

Natalia Varela-Andrés, Carlos Hernández-Del Caño, Alejandro Cebrián-León, Adrián Blanco, Izaskun Los Arcos-López de Pariza, Inés S Fernández Del Campo, Sandra García-Losada, Juan Carlos Arévalo, Manuel Sánchez-Martín, Raquel Bajo-Grañeras and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular psychiatry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Natalia Varela-Andrés *Instituto de Neurociencias de Castilla y León (INCyL). Universidad de Salamanca, Salamanca, Spain.ORCID http://orcid.org/0000-0003-3334-7521
Carlos Hernández-Del Caño *Instituto de Neurociencias de Castilla y León (INCyL). Universidad de Salamanca, Salamanca, Spain.ORCID http://orcid.org/0009-0003-4223-936X
Alejandro Cebrián-LeónInstituto de Neurociencias de Castilla y León (INCyL). Universidad de Salamanca, Salamanca, Spain.ORCID http://orcid.org/0000-0003-2779-7657
Adrián BlancoInstituto de Neurociencias de Castilla y León (INCyL). Universidad de Salamanca, Salamanca, Spain.ORCID http://orcid.org/0009-0005-7316-7156
Izaskun Los Arcos-López de ParizaDepartamento de Fisiología, Universidad Complutense de Madrid. Instituto Universitario de Investigación en Neuroquímica, Madrid, Spain.ORCID http://orcid.org/0009-0007-2491-8886
Inés S Fernández Del CampoInstituto de Neurociencias de Castilla y León (INCyL). Universidad de Salamanca, Salamanca, Spain.ORCID http://orcid.org/0000-0002-5034-7139
Sandra García-LosadaInstituto de Neurociencias de Castilla y León (INCyL). Universidad de Salamanca, Salamanca, Spain.ORCID http://orcid.org/0009-0003-2013-3070
Juan Carlos ArévaloInstituto de Neurociencias de Castilla y León (INCyL). Universidad de Salamanca, Salamanca, Spain.ORCID http://orcid.org/0000-0003-1994-3095
Manuel Sánchez-MartínInstituto de Investigación Biomédica de Salamanca (IBSAL), Salamanca, Spain.ORCID http://orcid.org/0000-0001-8370-1336
Raquel Bajo-GrañerasDepartamento de Fisiología, Universidad Complutense de Madrid. Instituto Universitario de Investigación en Neuroquímica, Madrid, Spain.ORCID http://orcid.org/0000-0001-8634-0687
Ricardo MartínDepartamento de Fisiología, Universidad Complutense de Madrid. Instituto Universitario de Investigación en Neuroquímica, Madrid, Spain.ORCID http://orcid.org/0000-0002-7645-4901
Alberto Sánchez-AguileraDepartamento de Fisiología, Universidad Complutense de Madrid. Instituto Universitario de Investigación en Neuroquímica, Madrid, Spain.
Miguel A MerchánInstituto de Neurociencias de Castilla y León (INCyL). Universidad de Salamanca, Salamanca, Spain.ORCID http://orcid.org/0000-0002-1334-2822
Rubén DeograciasInstituto de Neurociencias de Castilla y León (INCyL). Universidad de Salamanca, Salamanca, Spain. rdeogracias@usal.es.ORCID http://orcid.org/0000-0002-9279-7867

Funding

EC | Directorate-General for Employment, Social Affairs and Inclusion | European Social Fund (Fondo Social Europeo) PREP2023-001154
6 · The paper itself

Abstract

Brain-derived neurotrophic factor (BDNF) is a master regulator of neuronal differentiation and inhibitory circuit maturation in the mammalian brain. Yet, its downstream mediators in distinct neuronal populations remain incompletely defined. Here, we identify mitogen- and stress-activated kinase 1 (MSK1) as a critical mediator of BDNF signalling during postnatal striatal development. MSK1 expression predominates in GABAergic neurons across the cortex and striatum, with region-specific dynamics: MSK1 expression in cortical GABAergic interneurons declines from postnatal day 5 (P5) to day 30 (P30), while expression in striatal GABAergic medium spiny neurons (MSNs) persists into adulthood. Using a novel Msk1

Indexed as

Brain-Derived Neurotrophic FactorMethyl-CpG-Binding Protein 2Ribosomal Protein S6 Kinases, 90-kDaAnimalsCorpus StriatumGABAergic NeuronsMaleMedium Spiny NeuronsMiceMice, Inbred C57BLMice, KnockoutNeurodevelopmentNeuronsPhosphorylationSignal TransductionBdnf protein, mouseBrain-Derived Neurotrophic FactorMecp2 protein, mouseMethyl-CpG-Binding Protein 2mitogen and stress-activated protein kinase 1Ribosomal Protein S6 Kinases, 90-kDa

Identifiers

PMID42151442
PMCPMC13441968

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.