ArticleScientific reports2026
Green-synthesized silver nanoparticles optimized by Taguchi method inhibit urease activity in antibiotic-resistant helicobacter pylori.
Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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5 authors.
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Abstract
Helicobacter pylori (H. pylori) infection remains a significant global health challenge, contributing to various gastrointestinal disorders, including peptic ulcers and gastric cancer. The bacterium's urease enzyme plays a pivotal role in its survival by neutralizing gastric acidity, making urease inhibitors a promising therapeutic strategy. This study explores the green synthesis of silver nanoparticles (AgNPs) using Persian lime (Citrus latifolia T.) fruit extract as a reducing and stabilizing agent, optimized via the Taguchi method to achieve minimal particle size for enhanced bioactivity. Characterization techniques such as Fourier-transform infrared spectroscopy (FT-IR), dynamic light scattering (DLS), transmission electron microscopy (TEM), X-ray diffraction (XRD), and UV-Vis spectroscopy confirmed the formation of spherical AgNPs with an average size of 27.63 nm and a zeta potential of -13.8 mV, indicating good stability. The green synthesized AgNPs exhibited potent urease inhibitory activity, with an IC
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