Evidence map›Paper›PMID 42151316›Full record

ArticleScientific reports2026

Characterization of Alternaria alternata alternariol monomethyl ether with a potential antiproliferative activity by topoisomerases inhibition; molecular docking and dynamic simulations.

Ashraf S A El-Sayed, Moustafa O Aboelez, Hend A A Ezelarab, Tassneim M Ewedah, Ashraf F El-Baz, Radwa Ashraf, Ayman Diab, Gehan Safwat, Amgad M Rady, Rasha M El-Mekkawy

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Ashraf S A El-SayedEnzymology and Fungal Biotechnology Lab, Botany and Microbiology Department, Faculty of Science, Zagazig University, Zagazig, 44519, Egypt. ash.elsayed@gmail.com.
Moustafa O AboelezDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Sohag University, Sohag, 82524, Egypt.
Hend A A EzelarabDepartment of Medicinal Chemistry, Faculty of Pharmacy, Minia University, Minia City, 61519, Egypt.
Tassneim M EwedahPharmaceutics and Pharmaceutical Technology Department, Faculty of Pharmacy, Egyptian Russian University, Cairo, Egypt.
Ashraf F El-BazDepartment of Industrial Biotechnology, Genetic Engineering and Biotechnology Research Institute, University of Sadat City, 32897, Sadat City, Egypt.
Radwa AshrafFaculty of Biotechnology, October University for Modern Sciences and Arts, Giza, Egypt.
Ayman DiabFaculty of Biotechnology, October University for Modern Sciences and Arts, Giza, Egypt.
Gehan SafwatFaculty of Biotechnology, October University for Modern Sciences and Arts, Giza, Egypt.
Amgad M RadyEnzymology and Fungal Biotechnology Lab, Botany and Microbiology Department, Faculty of Science, Zagazig University, Zagazig, 44519, Egypt.
Rasha M El-MekkawyEnzymology and Fungal Biotechnology Lab, Botany and Microbiology Department, Faculty of Science, Zagazig University, Zagazig, 44519, Egypt.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The drug resistance is one of the challenges in cancer chemotherapy, due to the development of different drug-efflux pumps that expels the drug out of the cells, thus, searching for new compounds with multiple targets in tumor cells, could be an affordable chemotherapy. Alternariol monomethyl ether (AME) was preliminary recognized as a cytotoxic compound, however, its availability and equivocal activity are the hurdles for further applications. Alternaria alternata EFBL-025, PV342518.1, endophyte of Catharanthus roseus, exhibited the highest AME productivity (550 μg/l). Chemically, the structure of putative compound of A. alternata was committed from the TLC, HPLC and LC-MS/MS, with molecular mass 274.2 m/z, and typical fragmentation pattern of authentic AME. The purified AME of A. alternata exhibited a substantial activity against the MCF-7 (IC

Indexed as

AlternariaAntineoplastic AgentsLactonesTopoisomerase InhibitorsApoptosisCell Line, TumorCell ProliferationDNA Topoisomerases, Type IIHumansMCF-7 CellsMolecular Docking SimulationMolecular Dynamics Simulationalternariol monomethyl etherAntineoplastic AgentsDNA Topoisomerases, Type IILactonesTopoisomerase InhibitorsAlternaria alternateAlternariol monomethyl etherAnticancer activityMolecular dockingTopoisomerases inhibitor

Identifiers

PMID42151316
PMCPMC13184112

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.