Evidence map›Paper›PMID 42151283›Full record

ArticleScientific reports2026

Repeated intravesical platelet-rich plasma injections alleviate symptoms via T-cell modulation and mitochondrial dysfunction in non-ulcer interstitial cystitis/bladder pain syndrome.

Weilin Fang, Lin Liu, Xin Song, Jin Huang, Rong Lv, Ziwei Li, Tingting Lv, Zhikang Cai, Zhong Wang, Conghui Han and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Weilin Fang *Department of Urology, Pudong Gongli Hospital, Shanghai University of Medicine & Health Sciences, No. 219 Miaopu Road, Pudong New Area, Shanghai, 200135, China.
Lin Liu *Department of Urology, Xuzhou Central Hospital, No. 199 Jiefang South Road, Quanshan District, Xuzhou, 221009, Jiangsu Province, China.
Xin SongDepartment of Urology, Pudong Gongli Hospital, Shanghai University of Medicine & Health Sciences, No. 219 Miaopu Road, Pudong New Area, Shanghai, 200135, China.
Jin HuangDepartment of Urology, Pudong Gongli Hospital, Shanghai University of Medicine & Health Sciences, No. 219 Miaopu Road, Pudong New Area, Shanghai, 200135, China.
Rong LvDepartment of Urology, Pudong Gongli Hospital, Shanghai University of Medicine & Health Sciences, No. 219 Miaopu Road, Pudong New Area, Shanghai, 200135, China.
Ziwei LiDepartment of Urology, Pudong Gongli Hospital, Shanghai University of Medicine & Health Sciences, No. 219 Miaopu Road, Pudong New Area, Shanghai, 200135, China.
Tingting LvDepartment of Urology, Pudong Gongli Hospital, Shanghai University of Medicine & Health Sciences, No. 219 Miaopu Road, Pudong New Area, Shanghai, 200135, China.
Zhikang CaiDepartment of Urology, Pudong Gongli Hospital, Shanghai University of Medicine & Health Sciences, No. 219 Miaopu Road, Pudong New Area, Shanghai, 200135, China.
Zhong WangDepartment of Urology, Pudong Gongli Hospital, Shanghai University of Medicine & Health Sciences, No. 219 Miaopu Road, Pudong New Area, Shanghai, 200135, China.
Conghui HanDepartment of Urology, Xuzhou Central Hospital, No. 199 Jiefang South Road, Quanshan District, Xuzhou, 221009, Jiangsu Province, China. hanconghuidoctor@vip.qq.com.
Jianwei LvDepartment of Urology, Pudong Gongli Hospital, Shanghai University of Medicine & Health Sciences, No. 219 Miaopu Road, Pudong New Area, Shanghai, 200135, China. ljwass2020@163.com.

Funding

Clinical research projects initiated by researchers of Shanghai Pudong New Area Health Commission 2025-PWDL-10Key Discipline Development Initiative of the Shanghai Health System 2024ZDXK0043National Key Clinical Specialty Construction Project 10000015Z155080000004New Quality Clinical Specialty Program of High-end Medical Disciplinary Construction in Shanghai Pudong New Area 2024-PWXZ-13The Medical Discipline Construction Program of Shanghai Pudong New Area Health Commission PWZzb2025-05
6 · The paper itself

Abstract

Repeated intravesical injections of autologous platelet-rich plasma (PRP) have shown promise in alleviating symptoms of non-ulcer interstitial cystitis bladder pain syndrome (IC/BPS), but the underlying mechanisms remain unclear. In this single-center prospective study, 80 patients received four monthly PRP injections, with outcomes assessed by symptom scales, urodynamic parameters, and immune indices in urine and serum. PRP significantly reduced 24-h micturition frequency, numeric rating scale (NRS), O'Leary, pelvic pain and urgency/frequency patient symptom scale (PUF), and self-rating anxiety scale (SAS) scores at post-treatment follow-ups (all p < 0.05), while bladder capacity and voided volume remained unchanged. Serum and urinary inflammatory, iron metabolism, and oxidative stress markers were not significantly altered. PRP improved T-lymphocyte mitochondrial metabolic status, reducing CD4

Indexed as

Cystitis, InterstitialPlatelet-Rich PlasmaT-LymphocytesAdministration, IntravesicalAdultFemaleHumansMaleMembrane Potential, MitochondrialMiddle AgedProspective StudiesUrinationUrodynamicsInterstitial cystitis/bladder pain syndromePlatelet-rich plasmaT cell immune dysfunction

Identifiers

PMID42151283
PMCPMC13377193

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.