Evidence map›Paper›PMID 42151241›Full record

ArticleScientific reports2026

Tanshinone IIA inhibits foam cell formation and alleviates atherosclerosis by regulating the Hedgehog signaling pathway through TRPM2 suppression.

Yajuan Yin, Xiaocui Shi, Wenyun Tan, Xiao Zhang, Xiufang Jiang, Mei Liu, Jianan Xu, Da Liu, Le Wang, Mei Wei and 3 more

Abstract read
In one paragraph

Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Yajuan Yin *Central Laboratory, The First Hospital of Hebei Medical University, Shijiazhuang, 050000, Hebei, China.
Xiaocui Shi *Department of Cardiology, The First Hospital of Hebei Medical University, Shijiazhuang, 050000, Hebei, China.
Wenyun Tan *Department of Emergency, The First Hospital of Hebei Medical University, Shijiazhuang, 050000, Hebei, China.
Xiao ZhangDepartment of Cardiology, The First Hospital of Hebei Medical University, Shijiazhuang, 050000, Hebei, China.
Xiufang JiangDepartment of Medical Affairs, The First Hospital of Hebei Medical University, Shijiazhuang, 050000, Hebei, China.
Mei LiuDepartment of Cardiology, The First Hospital of Hebei Medical University, Shijiazhuang, 050000, Hebei, China.
Jianan XuDepartment of Cardiology, The First Hospital of Hebei Medical University, Shijiazhuang, 050000, Hebei, China.
Da LiuDepartment of Cardiology, The First Hospital of Hebei Medical University, Shijiazhuang, 050000, Hebei, China.
Le WangDepartment of Cardiology, The First Hospital of Hebei Medical University, Shijiazhuang, 050000, Hebei, China.
Mei WeiDepartment of Cardiology, The First Hospital of Hebei Medical University, Shijiazhuang, 050000, Hebei, China.
Gang LiuDepartment of Cardiology, The First Hospital of Hebei Medical University, Shijiazhuang, 050000, Hebei, China.
Fangfang MaDepartment of Cardiology, The First Hospital of Hebei Medical University, Shijiazhuang, 050000, Hebei, China. fangfangma1985@hotmail.com.
Mingqi ZhengDepartment of Cardiology, The First Hospital of Hebei Medical University, Shijiazhuang, 050000, Hebei, China. mzheng@hebmu.edu.cn.

Funding

Hebei Province Finance Department Project ZF2024133S&T Program of Hebei 22377719D
6 · The paper itself

Abstract

The development of foam cells is crucial in the advancement of atherosclerosis (AS). Tanshinone IIA (Tan IIA), the primary lipophilic component of Salvia miltiorrhiza, has various pharmacological effects. Despite this, the precise role of Tan IIA in AS has not been fully elucidated. In this research, we employed ApoE

Indexed as

AbietanesAtherosclerosisFoam CellsHedgehog ProteinsSignal TransductionTRPM Cation ChannelsAnimalsApolipoproteins ECalciumCholesterolDisease Models, AnimalMiceAbietanesApolipoproteins ECalciumCholesterolHedgehog ProteinstanshinoneTRPM2 protein, mouseTRPM Cation ChannelsAtherosclerosisFoam cell formationHedgehog signaling pathwayTanshinone IIATRPM2

Identifiers

PMID42151241
PMCPMC13377218

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.