Evidence map›Paper›PMID 42151181›Full record

ArticleNature communications2026

Chromatin- and actin-mediated mitochondrial streaming leads to patterning of mitochondrial distribution in oocytes.

In-Won Lee, Morteza Nazari, Jazmine Yuson, Sanjeev Uthishtran, Ross Stocker, Deepak Adhikari, Zhong-Wei Wang, Gyorgy Szabadkai, Michael R Duchen, Senthil Arumugam and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

In-Won LeeDevelopment and Stem Cells Program and Department of Anatomy and Developmental Biology, Monash Biomedicine Discovery Institute, Monash University, Melbourne, VIC, Australia. inwon.lee1@monash.edu.ORCID http://orcid.org/0000-0003-4336-5897
Morteza NazariDepartment of Mechanical and Aerospace Engineering, Monash University, Melbourne, VIC, Australia.ORCID http://orcid.org/0000-0003-2730-3602
Jazmine YusonDevelopment and Stem Cells Program and Department of Anatomy and Developmental Biology, Monash Biomedicine Discovery Institute, Monash University, Melbourne, VIC, Australia.ORCID http://orcid.org/0009-0004-6799-6938
Sanjeev UthishtranDevelopment and Stem Cells Program and Department of Anatomy and Developmental Biology, Monash Biomedicine Discovery Institute, Monash University, Melbourne, VIC, Australia.ORCID http://orcid.org/0000-0001-8538-3482
Ross StockerDevelopment and Stem Cells Program and Department of Anatomy and Developmental Biology, Monash Biomedicine Discovery Institute, Monash University, Melbourne, VIC, Australia.
Deepak AdhikariDevelopment and Stem Cells Program and Department of Anatomy and Developmental Biology, Monash Biomedicine Discovery Institute, Monash University, Melbourne, VIC, Australia.
Zhong-Wei WangDepartment of Cell and Developmental Biology and Consortium for Mitochondrial Research, University College London, London, UK.
Gyorgy SzabadkaiDepartment of Cell and Developmental Biology and Consortium for Mitochondrial Research, University College London, London, UK.ORCID http://orcid.org/0000-0002-3006-3577
Michael R DuchenDepartment of Cell and Developmental Biology and Consortium for Mitochondrial Research, University College London, London, UK.ORCID http://orcid.org/0000-0003-2548-4294
Senthil ArumugamDevelopment and Stem Cells Program and Department of Anatomy and Developmental Biology, Monash Biomedicine Discovery Institute, Monash University, Melbourne, VIC, Australia.ORCID http://orcid.org/0000-0001-6733-4679
Reza NosratiDepartment of Mechanical and Aerospace Engineering, Monash University, Melbourne, VIC, Australia.ORCID http://orcid.org/0000-0002-1461-229X
John CarrollDevelopment and Stem Cells Program and Department of Anatomy and Developmental Biology, Monash Biomedicine Discovery Institute, Monash University, Melbourne, VIC, Australia. j.carroll@monash.edu.ORCID http://orcid.org/0000-0001-9644-5861

Funding

Department of Health | National Health and Medical Research Council (NHMRC) 1165627Department of Health | National Health and Medical Research Council (NHMRC) 200112
6 · The paper itself

Abstract

Mitochondria are highly dynamic organelles, and their spatiotemporal organization is strictly regulated. While it has long been recognized that mitochondria in ovulated oocytes are concentrated in the spindle hemisphere, the mechanism remains unknown. Through live cell imaging and modeling, we have discovered that mitochondrial polarization in MII oocytes is achieved through two distinct mechanisms: (i) a mechanism in which mitochondria are transported by actin-driven cytoplasmic streaming that is delimited to the spindle hemisphere; (ii) an active, MYO19 dependent channeling mechanism that directs mitochondria from beneath the spindle to the polarized cortex bilaterally and perpendicular to the long axis of the MII spindle. This directionality in mitochondrial streaming patterns the ooplasm of the spindle hemisphere, creating mitochondria-rich and mitochondria-poor regions. These features explain the establishment of the polar gradient of mitochondria in MII oocytes and may provide new insight into the spatiotemporal organization of mitochondria in cells.

Indexed as

ActinsChromatinCytoplasmic StreamingMitochondriaOocytesAnimalsFemaleMyosinsSpindle ApparatusXenopus laevisActinsChromatinMyosins

Identifiers

PMID42151181
PMCPMC13381949

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.