ArticleMicrosystems & nanoengineering2026
A high-throughput modular microfluidic platform for versatile functional assays at single-cell level.
Article in Microsystems & nanoengineering, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
1 citing paper in PubMed.
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Authors and funding
4 authors.
Funding
Abstract
Understanding how individual cells behave is essential for uncovering the complexity of biology and disease, yet most single-cell technologies provide only static molecular snapshots. We present the High-throughput Single-Cell Omni-functional Profiling Engine (HiSCOPE), a microfluidic platform that directly investigates functional dynamics of ≥10,000 single cells. HiSCOPE integrates a hydrodynamic single-cell trapping array with customized modular assay chambers to reproducibly trap single cells, pairs, and trios of cells originating from distinct populations and to support diverse functional assays-including viability, proliferation, cytotoxicity, cytokine secretion, and contact-dependent and -independent cell-cell interactions. Importantly, live-cell retrieval enables downstream analysis of selected cells. We demonstrate HiSCOPE's utility by evaluating leukemia cells' drug susceptibility, profiling natural killer (NK) cell cytotoxicity and cytokine secretion, and dissecting T cell-macrophage crosstalk. Our results reveal striking functional diversity that is masked in bulk assays. HiSCOPE offers a scalable solution for functional profiling of single cells, with broad implications for biology, immunotherapy, and personalized medicine.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.