Evidence map›Paper›PMID 42151112›Full record

ArticleBone research2026

A RANKL

Jinbo Li, Jinxiao Fan, Zhenqiang Yao, Han Jiao, Rong Duan, James O Sanders, Addisu Mesfin, Lianping Xing, Brendan F Boyce

Abstract read
In one paragraph

Article in Bone research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Total saponins fromJournal of ginseng research · 2026
    Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jinbo LiDepartment of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, NY, USA. Jinbo_Li@hebmu.edu.cn.ORCID 0000-0003-1565-4173
Jinxiao FanHebei Key Laboratory of Cardiovascular Homeostasis and Aging, Hebei Medical University, Shijiazhuang, Hebei, China.
Zhenqiang YaoDepartment of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, NY, USA.ORCID 0000-0002-4664-3648
Han JiaoHebei Key Laboratory of Cardiovascular Homeostasis and Aging, Hebei Medical University, Shijiazhuang, Hebei, China.
Rong DuanDepartment of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, NY, USA.
James O SandersDepartment of Orthopaedics and Rehabilitation Medicine, University of Rochester Medical Center, Rochester, NY, USA.
Addisu MesfinDepartment of Orthopaedics and Rehabilitation Medicine, University of Rochester Medical Center, Rochester, NY, USA.
Lianping XingDepartment of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, NY, USA.ORCID 0000-0002-2588-7766
Brendan F BoyceDepartment of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, NY, USA. brendan_boyce@urmc.rochester.edu.ORCID 0000-0002-3587-4854

Funding

Role of Macrophage in Osteoimmunology with AgingR01AG076731 · NIA · UNIVERSITY OF ROCHESTER · PI Zhenqiang Yao · 2022 to 2026
$2.1M
Synovial lymphatics and osteoarthritis in agingR01AG059775 · NIA · UNIVERSITY OF ROCHESTER · PI XING, LIANPING · 2020 to 2024
$1.9M
Studies of TRAF3 in age-related low-level chronic inflammation and osteoporosisR01AG049994 · NIA · UNIVERSITY OF ROCHESTER · PI BOYCE, BRENDAN F, YAO, ZHENQIANG · 2016 to 2020
$1.6M
National Natural Science Foundation of China (National Science Foundation of China) 82172469National Natural Science Foundation of China (National Science Foundation of China) 82472481U.S. Department of Health & Human Services | NIH | National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) R01AR43510U.S. Department of Health & Human Services | NIH | National Institute on Aging (U.S. National Institute on Aging) R01AG049994U.S. Department of Health & Human Services | NIH | National Institute on Aging (U.S. National Institute on Aging) R01AG059775U.S. Department of Health & Human Services | NIH | National Institute on Aging (U.S. National Institute on Aging) R01AG076731
6 · The paper itself

Abstract

RANKL induces bone loss in part by promoting degradation of TRAF3, levels of which decrease in murine and human bone during aging, but the major cellular sources of RANKL in bone marrow (BM) during aging are unknown. Here, we identify RANKL

Indexed as

AgingB-LymphocytesBone MarrowBone Marrow CellsOsteoporosisRANK LigandReceptors, CXCR4AnimalsBenzylaminesBone ResorptionChemokine CXCL12CyclamsFemaleHeterocyclic CompoundsMaleMesenchymal Stem CellsBenzylaminesChemokine CXCL12CXCR4 protein, mouseCyclamsHeterocyclic CompoundsplerixaforRANK LigandReceptors, CXCR4

Identifiers

PMID42151112
PMCPMC13183972

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.