Evidence map›Paper›PMID 42150848›Full record

ArticleLupus science & medicine2026

Comparison of BAFF and type I IFN activity in blood and placenta in SLE and healthy pregnancies.

Agnes Torell, Kerstin Andersson, Iva Gunnarsson, Elisabet Svenungsson, Agneta Zickert, Maria Majczuk Sennström, Estelle Trysberg, Anders A Bengtsson, Andreas Jönsen, Helena Strevens and 13 more

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Lupus science & medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors.

Agnes TorellDepartment of Rheumatology and Inflammation Research, Institute of Medicine, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden agnes.torell.bjorkman@gu.se.ORCID 0000-0002-5063-092X
Kerstin AnderssonDepartment of Rheumatology and Inflammation Research, Institute of Medicine, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden.
Iva GunnarssonDivision of Rheumatology, Department of Medicine Solna, Karolinska University Hospital, Stockholm, Sweden.
Elisabet SvenungssonDivision of Rheumatology, Department of Medicine Solna, Karolinska University Hospital, Stockholm, Sweden.ORCID 0000-0003-3396-3244
Agneta ZickertDivision of Rheumatology, Department of Medicine Solna, Karolinska University Hospital, Stockholm, Sweden.
Maria Majczuk SennströmDepartment of Women's and Children's Health, Division of Neonatology, Obstetrics, Gynaecology and Reproductive Health, Karolinska University Hospital, Stockholm, Sweden.
Estelle TrysbergRheumatology, Sahlgrenska University Hospital, Western Healthcare Region, Gothenburg, Sweden.
Anders A BengtssonDepartment of Clinical Sciences Lund, Rheumatology, Lund University, Skåne University Hospital Lund, Lund, Sweden.
Andreas JönsenDepartment of Clinical Sciences Lund, Rheumatology, Lund University, Skåne University Hospital Lund, Lund, Sweden.
Helena StrevensDepartment of Clinical Sciences Lund, Obstetrics and Gynecology, Skåne University Hospital Lund, Lund, Sweden.
Christopher SjöwallDivision of Inflammation and Infection, Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden.ORCID 0000-0003-0900-2048
Muna SalehDivision of Inflammation and Infection, Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden.ORCID 0000-0002-4836-6373
Sofia PihlDepartment of Biomedical and Clinical Sciences, Division of Children's and Women's Health, Linköping University, Linköping, Sweden.
Dag LeonardDepartment of Medical Sciences, Rheumatology, Uppsala University, Uppsala, Sweden.ORCID 0000-0002-6275-7282
Lars RonnblomDepartment of Medical Sciences, Rheumatology, Uppsala University, Uppsala, Sweden.ORCID 0000-0001-9403-6503
Tansim AkhterDepartment of Women's and Children's Health, Section of Obstetrics and Gynecology, Uppsala University, Uppsala, Sweden.
Fariba RoshanzamirDepartment of Life Sciences, National Bioinformatics Infrastructure Sweden, Science for Life Laboratory, Chalmers University of Technology, Gothenburg, Sweden.
Henrik ZetterbergDepartment of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden.
Johan BylundDepartment of Oral Microbiology and Immunology, Institute of Odontology, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden.
Bo JacobssonDepartment of Obstetrics and Gynecology, Sahlgrenska University Hospital, Western Healthcare Region, Gothenburg, Sweden.
Anna RudinDepartment of Rheumatology and Inflammation Research, Institute of Medicine, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden.
Anna-Carin LundellDepartment of Rheumatology and Inflammation Research, Institute of Medicine, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden.ORCID 0000-0002-4303-8266
Marit StockfeltDepartment of Rheumatology and Inflammation Research, Institute of Medicine, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo examine B cell-activating factor (BAFF) and type I interferon (IFN) activity at the transcriptional and protein levels in blood and placental tissue in SLE compared with healthy pregnancies to assess their relationship and to determine whether BAFF levels are associated with pregnancy outcomes in SLE.

methodsIn the SLE-Placenta study, we followed women with SLE (n=83) and healthy controls (n=67) throughout pregnancy. Blood samples were collected in all trimesters and at delivery from peripheral blood, placental intervillous blood and cord blood. Postpartum blood samples were obtained from a subset of women with SLE. Bulk messenger RNA (mRNA) sequencing was performed on peripheral blood mononuclear cells (PBMCs) and placental tissue from a subgroup of women with SLE and healthy controls. BAFF concentrations were measured by ELISA and IFNα protein levels by single-molecule array (Simoa).

resultsWomen with SLE had upregulated BAFF (

conclusionsPregnant women with SLE exhibited persistently elevated BAFF levels, which were associated with lower B cell numbers, SLE-related autoantibody positivity and shorter pregnancy duration. Together with a disease-specific placental enrichment of IFNα, these findings support the presence of an inflammatory and potentially pathogenic IFN-BAFF signature in SLE pregnancy. Further studies are needed to determine the functional consequences of these immunological alterations on maternal-fetal health in SLE.

Indexed as

B-Cell Activating FactorInterferon-alphaInterferon Type ILupus Erythematosus, SystemicPlacentaPregnancy ComplicationsAdultCase-Control StudiesFemaleFetal BloodHumansLeukocytes, MononuclearPregnancyPregnancy OutcomeB-Cell Activating FactorInterferon-alphaInterferon Type ITNFSF13B protein, humanAutoantibodiesInflammationLupus Erythematosus, Systemic

Identifiers

PMID42150848
PMCPMC13185015

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