Evidence map›Paper›PMID 42150794›Full record

ArticleBMJ open respiratory research2026

Clinical, imaging, bronchoscopic characteristics and pulmonary function features in patients with endobronchial tuberculosis: a single-centre cross-sectional study.

Cuong Kim Nguyen, The Manh Nguyen, Minh Le Nhat Nguyen, Dai Khac Vu, Phuong Anh Thi Nguyen, Thai Duc Truong, Luong Van Dinh

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Article in BMJ open respiratory research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

7 authors.

Cuong Kim NguyenRespiratory Tuberculosis Department, Vietnam National Lung Hospital, Hanoi, Vietnam cuongoc@hmu.edu.vn.
The Manh NguyenRespiratory Tuberculosis Department, Vietnam National Lung Hospital, Hanoi, Vietnam.ORCID http://orcid.org/0009-0003-4469-1050
Minh Le Nhat NguyenDepartment of Diagnostic Endoscopy, Vietnam National Lung Hospital, Hanoi, Vietnam.
Dai Khac VuDepartment of Diagnostic Endoscopy, Vietnam National Lung Hospital, Hanoi, Vietnam.
Phuong Anh Thi NguyenFunctional Examination and Rehabilitation Department, Vietnam National Lung Hospital, Hanoi, Vietnam.
Thai Duc TruongRespiratory Tuberculosis Department, Vietnam National Lung Hospital, Hanoi, Vietnam.
Luong Van DinhLung Transplant Center, National Lung Hospital, Hanoi, Vietnam.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesEndobronchial tuberculosis (EBTB) is a common manifestation of tuberculosis (TB) that may cause airway obstruction if not promptly diagnosed and treated. This study described clinical, imaging, bronchoscopic characteristics and pulmonary function in patients with EBTB.

designA single-centre cross-sectional study.

settingThe study was conducted at the National Lung Hospital, a tertiary hospital specialised in TB and lung diseases in Vietnam from May 2023 to May 2024.

participantsWe consecutively enrolled 91 patients aged ≥16 years with bacteriologically confirmed EBTB, defined by positive OUTCOME MEASURES: The outcome of our study was the presence of central airway obstruction (CAO), defined as ≥50% narrowing of the trachea, mainstem bronchi, bronchus intermedius, lobar and segmental bronchi visually estimated on bronchoscopy and supported by HRCT findings.

resultsMedian age was 37 years (IQR: 27-54), 64.8% female; 31.9% were post-TB treatment cases and 68.1% newly diagnosed. Overall, 65.9% of patients had ventilatory defects, most commonly the restrictive pattern (66.7%). Lesions were more frequent in the left airway than right (64.8% vs 31.9%, p<0.001). CAO was found in 71.4% of patients, more common in post-TB cases (86.2% vs 64.5%). Multivariate logistic regression analyses showed that three variables were independently associated with the risk of CAO on bronchoscopy, including shorter duration from symptom onset to hospitalisation (<8 weeks) (adjusted OR (aOR) = 3.93, 95% CI 1.18 to 13.03), dyspnoea (aOR = 3.85, 95% CI 1.27 to 11.68) and forced expiratory volume in one second (FEV

conclusionVentilatory defects and CAO were common among patients with EBTB. A high level of suspicion should be applied to patients presenting with dyspnoea, shorter duration from symptom onset to hospitalisation (<8 weeks) and reduced FEV

Indexed as

Airway ObstructionBronchoscopyTuberculosis, PulmonaryAdultBronchiCross-Sectional StudiesFemaleHumansMaleMiddle AgedMycobacterium tuberculosisRespiratory Function TestsSpirometryTomography, X-Ray ComputedVietnamRespiratory Function TestTuberculosis

Identifiers

PMID42150794
PMCPMC13185006

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