Evidence map›Paper›PMID 42150793›Full record

ArticleBMJ open respiratory research2026

Early-life lung function deficits partially explain the link between maternal asthma and bronchiolitis or asthma in offspring.

Carla Rebeca Da Silva Sena, Adam Collison, Vanessa E Murphy, Gabriela Martins Costa Gomes, Olga Gorlanova, Noëmi Künstle, Céline Rüttimann, Sven Schulzke, Benjamin Stoecklin, Jakob Usemann and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ open respiratory research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Carla Rebeca Da Silva SenaUniversity Children's Hospital Basel UKBB, University of Basel, Basel, Switzerland carla.dasilva@ukbb.ch joerg.mattes@newcastle.edu.au urs.frey@ukbb.ch.ORCID http://orcid.org/0000-0002-6424-7796
Adam CollisonHunter Medical Research Institute and Asthma & Breathing research program, The University of Newcastle, Newcastle, New South Wales, Australia.
Vanessa E MurphyHunter Medical Research Institute and Asthma & Breathing research program, The University of Newcastle, Newcastle, New South Wales, Australia.ORCID http://orcid.org/0000-0003-3282-1324
Gabriela Martins Costa GomesHunter Medical Research Institute and Asthma & Breathing research program, The University of Newcastle, Newcastle, New South Wales, Australia.
Olga GorlanovaUniversity Children's Hospital Basel UKBB, University of Basel, Basel, Switzerland.
Noëmi KünstleUniversity Children's Hospital Basel UKBB, University of Basel, Basel, Switzerland.
Céline RüttimannUniversity Children's Hospital Basel UKBB, University of Basel, Basel, Switzerland.
Sven SchulzkeUniversity Children's Hospital Basel UKBB, University of Basel, Basel, Switzerland.
Benjamin StoecklinUniversity Children's Hospital Basel UKBB, University of Basel, Basel, Switzerland.
Jakob UsemannUniversity Children's Hospital Basel UKBB, University of Basel, Basel, Switzerland.
Ruth SteinbergDepartment of Paediatrics, Inselspital University Hospital Bern, Division of Paediatric Respiratory Medicine and Allergology, Bern, Switzerland.ORCID http://orcid.org/0000-0003-4108-6085
Sophie YammineDepartment of Paediatrics, Inselspital University Hospital Bern, Division of Paediatric Respiratory Medicine and Allergology, Bern, Switzerland.
Paul D RobinsonDepartment of Respiratory Medicine, The Children's Hospital at Westmead, Sydney, New South Wales, Australia.
Peter D SlySouth Brisbane, Children's Health and Environment Program, Child Health Research Centre, The University of Queensland, Brisbane, Queensland, Australia.
Philipp LatzinUniversity Children's Hospital Basel UKBB, University of Basel, Basel, Switzerland.
Peter G GibsonHunter Medical Research Institute and Asthma & Breathing research program, The University of Newcastle, Newcastle, New South Wales, Australia.
Urs FreyUniversity Children's Hospital Basel UKBB, University of Basel, Basel, Switzerland carla.dasilva@ukbb.ch joerg.mattes@newcastle.edu.au urs.frey@ukbb.ch.
Joerg MattesHunter Medical Research Institute and Asthma & Breathing research program, The University of Newcastle, Newcastle, New South Wales, Australia carla.dasilva@ukbb.ch joerg.mattes@newcastle.edu.au urs.frey@ukbb.ch.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMaternal asthma during pregnancy is associated with an increased risk of bronchiolitis and asthma in offspring, but the mechanisms remain poorly understood. We aimed to assess whether impaired postnatal infant lung function independently influences the risk of bronchiolitis and asthma in childhood or whether it mediates the association between maternal asthma during pregnancy and respiratory outcomes.

methodsWe analysed harmonised infant lung function data from two birth cohorts: the Australian Breathing for Life Trial and the Swiss Basel-Bern Infant Lung Development. Bronchiolitis hospitalisation (verified through medical records) and asthma at age six (parent-reported) were primary outcomes. Lung function measured included the ratio of maximum tidal inspiratory flow to maximum tidal expiratory flow (MTIF/MTEF) and the time to peak tidal expiratory flow to total expiratory time ratio, tPTEF/tE. Multivariable logistic regression assessed associations, and generalised structural equation modelling was used for mediation analyses.

resultsThe study included 1203 term infants with 89 cases of bronchiolitis hospitalisation. Tidal breathing lung function ratios were associated with bronchiolitis hospitalisations: MTIF/MTEF adjusted ORs (aORs) 2.90, 95% CI 1.20 to 7.02, p=0.018; asthma in childhood: tPTEF/tE aOR 0.97, 95% CI 0.94 to 0.99, p=0.013 and MTIF/MTEF aOR 2.94, 95% CI 1.07 to 8.02, p=0.036. MTIF/MTEF ratio mediated 11% of the total effect of asthma during pregnancy on bronchiolitis risk, and MTIF/MTEF and tPTEF/tE ratios mediated 3% of the effect of asthma during pregnancy on childhood asthma risk.

conclusionPostnatal lung function was associated with subsequent bronchiolitis and childhood asthma. Additionally, the effect of maternal asthma during pregnancy on the outcomes was partially mediated by impaired lung function.

Indexed as

AsthmaBronchiolitisLungPregnancy ComplicationsPrenatal Exposure Delayed EffectsAdultAustraliaBirth CohortChildFemaleHospitalizationHumansInfantInfant, NewbornMalePregnancyAsthmaAsthma EpidemiologyPaediatric asthmaRespiratory Function Test

Identifiers

PMID42150793
PMCPMC13185018

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.