Evidence map›Paper›PMID 42150759›Full record

ArticleAmerican journal of respiratory cell and molecular biology2026

Upper and Lower Respiratory Tract Compartmentalization in Pediatric Stem Cell Transplantation.

Erica M Evans, Madeline Y Mayday, Emma M Pearce, Kensho Iwanaga, Ngoc P Ly, Gwynne D Church, Gustavo Reyes, Miriam R Simon, Jacob Blum, Hanna Kim and 25 more

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In one paragraph

Article in American journal of respiratory cell and molecular biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

35 authors.

Erica M EvansDivision of Critical Care Medicine, Department of Pediatrics, University of California, San Francisco, San Francisco, CA, United States.
Madeline Y MaydayDivision of Critical Care Medicine, Department of Pediatrics, University of California, San Francisco, San Francisco, CA, United States.
Emma M PearceDivision of Critical Care Medicine, Department of Pediatrics, University of California, San Francisco, San Francisco, CA, United States.
Kensho IwanagaDivision of Pulmonary Medicine, Department of Pediatrics, University of California, San Francisco, San Francisco, CA, United States.
Ngoc P LyDivision of Pulmonary Medicine, Department of Pediatrics, University of California, San Francisco, San Francisco, CA, United States.
Gwynne D ChurchDivision of Pulmonary Medicine, Department of Pediatrics, University of California, San Francisco, San Francisco, CA, United States.
Gustavo ReyesDivision of Critical Care Medicine, Department of Pediatrics, University of California, San Francisco, San Francisco, CA, United States.
Miriam R SimonDivision of Critical Care Medicine, Department of Pediatrics, University of California, San Francisco, San Francisco, CA, United States.
Jacob BlumDivision of Critical Care Medicine, Department of Pediatrics, University of California, San Francisco, San Francisco, CA, United States.
Hanna KimDivision of Critical Care Medicine, Department of Pediatrics, University of California, San Francisco, San Francisco, CA, United States.
Jessica MuDivision of Critical Care Medicine, Department of Pediatrics, University of California, San Francisco, San Francisco, CA, United States.
Jazmin Baez-MaidanaDivision of Critical Care Medicine, Department of Pediatrics, University of California, San Francisco, San Francisco, CA, United States.
Jeffrey J AulettaHematology/Oncology/BMT and Infectious Diseases, Nationwide Children's Hospital, Columbus, OH, United States.
Peter J ShawThe Children`s Hospital at Westmead, Westmead, NSW, Australia.
Erin M KremlDepartment of Child Health, Division of Critical Care Medicine, University of Arizona, Phoenix, AZ, United States.
Paul L MartinDivision of Pediatric and Cellular Therapy, Duke University Medical Center, Durham, NC, United States.
Christine N DuncanHarvard Medical School, Boston, MA, ; Division of Pediatric Oncology, Department of Pediatrics, Dana-Farber Cancer Institute and Boston Children's Hospital, Boston, MA, United States.
Courtney M RowanDepartment of Pediatrics, Division of Critical Care Medicine, Indiana University, Indianapolis, IN, United States.
Kamar GodderCancer and Blood Disorders Center, Nicklaus Children's Hospital, Miami, FL, United States.
Caitlin HurleyDivision of Critical Care, Department of Pediatric Medicine, St Jude Children's Research Hospital, Memphis, TN, United States.
Geoffrey D E CuvelierCancerCare Manitoba, Manitoba Blood and Marrow Transplant Program, University of Manitoba, Winnipeg, Manitoba, Canada.
Muna QayedAflac Cancer & Blood Disorders Center, Children's Healthcare of Atlanta and Emory University, Atlanta, GA, United States.
Hisham Abdel-AzimDepartment of Pediatrics, Division of Hematology/Oncology and Transplant and Cell Therapy, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States.
Amy K KeatingHarvard Medical School, Boston, MA, ; Division of Pediatric Oncology, Department of Pediatrics, Dana-Farber Cancer Institute and Boston Children's Hospital, Boston, MA, United States.
Julie C FitzgeraldDepartment of Anesthesiology and Critical Care, Perelman School of Medicine, Children's Hospital of Philadelphia, University of Pennsylvania, Philadelphia, PA, United States.
Rabi HannaDepartment of Pediatric Hematology, Oncology and Blood and Marrow Transplantation, Pediatric Institute, Cleveland Clinic, Cleveland, OH, United States.
James S KillingerDivision of Pediatric Critical Care, Department of Pediatrics, Weill Cornell Medicine, New York, NY, United States.
Janet R HumeDepartment of Pediatrics, Division of Critical Care Medicine, University of Minnesota, Minneapolis, MN, United States.
Troy C QuiggPediatric Blood and Marrow Transplantation Program, Texas Transplant Institute, Methodist Children's Hospital, San Antonio, TX, United States.
Paul CastilloUniversity of Florida, Gainesville, UF Health Shands Children's Hospital, Gainesville, FL, United States.
Prakash SatwaniDivision of Pediatric Hematology, Oncology and Stem Cell Transplantation, Department of Pediatrics, Columbia University, New York, NY, United States.
Theodore B MooreDepartment of Pediatric Hematology-Oncology, Mattel Children's Hospital, University of California, Los Angeles, CA, United States.
Christopher C DvorakDivision of Allergy, Immunology, and Bone Marrow Transplantation, Department of Pediatrics, University of California, San Francisco, San Francisco, CA, United States.
Matt S ZinterDivision of Critical Care Medicine, Department of Pediatrics, University of California, San Francisco, San Francisco, CA, United States.
Pediatric Transplantation And Cell Therapy Consortium

Funding

Pulmonary Immune Regulation of Lung Injury after Pediatric Hematopoietic Cell TransplantR01HL180864 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Matthew Scott Zinter · 2025 to 2026
$1.4M
Pathobiologic Transcriptional Signatures of Pulmonary Complications in Pediatric Hematopoietic Cellular TransplantationK23HL146936 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ZINTER, MATTHEW SCOTT · 2020 to 2024
$980k
Investigation of pulmonary fibrosis biology in pediatric hematopoietic cell transplant patientsR03HL171423 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ZINTER, MATTHEW SCOTT · 2024 to 2025
$253k
NHLBI NIH HHS K23 HL146936NHLBI NIH HHS R01 HL180864NHLBI NIH HHS R03 HL171423
6 · The paper itself

Abstract

rationaleLung injury after hematopoietic stem cell transplantation (HCT) occurs due to infection, chemotherapy toxicity, and alloreactive inflammation. Analyses of bronchoalveolar lavage (BAL) fluid have revealed dominant pathobiologic signatures, but minimally-invasive diagnostics are needed.

objectivesTo determine whether microbiome and gene expression perturbations are shared along the respiratory tract or isolated to the alveoli in pediatric HCT patients with lung injury.

methodsWe performed bulk RNA sequencing on 206 paired nasal and BAL samples from 160 HCT patients and 17 healthy controls enrolled at 28 children's hospitals (2016-2025). Microbial and human transcripts were compared using multivariable models accounting for age, sex, and paired sampling. MEASUREMENTS AND MAIN

resultsHCT BAL and nasal transcriptomes differed across 13,698 genes, 48 cellular components, and network interactions linking inflammation, reactive oxygen species, and immunometabolism. Minimal BAL-nasal correlation was observed in gene expression levels (median ρ = 0.03, IQR -0.03 to 0.08) or fractional abundance of key cells such as neutrophils and CD8 + T-cells. BAL microbiomes harbored fewer commensal bacteria and more fungi and DNA viruses. BAL bacterial RNA was associated with diminished immune signaling whereas nasal bacterial RNA aligned with inflammatory gene expression. Further, only BAL microbial RNA was linked to transcriptional shifts in epithelial injury response, keratinization, and collagen deposition. Finally, BAL commensal microbiome depletion, epithelial injury, and immune dysregulation signatures were associated with death or prolonged mechanical ventilation, whereas nasal samples provided minimal prognostic information.

conclusionsThese data support alveolar compartmentalization in pediatric HCT and emphasize the ongoing need for minimally-invasive but informative diagnostics.

Indexed as

Bronchoalveolar LavageHematopoietic Stem Cell TransplantationImmunocompromised HostIntensive Care UnitsPediatricTranscriptome

Identifiers

PMID42150759
PMCPMC13335405

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.