ReviewRedox biology2026
Impact of mitochondrial reductive stress due to respiratory chain limitation on cancer via posttranslational modifications.
Review in Redox biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Aglycemia triggers alternative electron transport to sustain mesenchymal stem cell survival under anoxia.Redox biology · 2026Article
- A CD44-targeted PDA/ZnO redox-active nanocomposite that couples chemotherapy with mitochondrial stress and tumor immune remodeling.Journal of nanobiotechnology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Respiratory chain limitation is a recurrent but spatially heterogeneous state in solid tumors, driven by hypoxic subregions, electron transport chain defects, and signaling- or therapy-imposed respiratory inhibition. Restricted electron flow supports an ETC-linked MRS state characterized by accumulation of reduced electron carriers and configuration-dependent reactive oxygen species formation. This review describes how electron transport chain limitation remodels posttranslational modifications through (i) oxygen partitioning and substrate control of oxygen-dependent dioxygenases -considering that respiratory complex IV is the dominant intracellular molecular oxygen sink, thus shaping its availability for hydroxylation and demethylation reactions- and (ii) redox backpressure that shifts NAD(P)
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Registered trials
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