Evidence map›Paper›PMID 42150282›Full record

ArticleEpilepsy research2026

Is temporal lobe epilepsy a progressive disease? Insights from a 5-HT

Giampiero Giovacchini, Andrea Marciano, Shubhi Agrawal, William H Theodore

Abstract read
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In one paragraph

Article in Epilepsy research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Giampiero GiovacchiniNuclear Medicine Department, Sant'Andrea Hospital, La Spezia, Italy. Electronic address: giampiero.giovacchini@asl5.liguria.it.
Andrea MarcianoNuclear Medicine Department, Sant'Andrea Hospital, La Spezia, Italy. Electronic address: andrea.marciano@asl5.liguria.it.
Shubhi AgrawalClinical Epilepsy Section, National Institute of Neurological Disorders and Strokes, National Institutes of Health, Bethesda, MD, USA; Department of Neurology, University of California, Davis, USA. Electronic address: drshubhiagrawal@gmail.com.
William H TheodoreClinical Epilepsy Section, National Institute of Neurological Disorders and Strokes, National Institutes of Health, Bethesda, MD, USA. Electronic address: theodorw@ninds.nih.gov.

Funding

Intramural NIH HHS Z99 NS999999
6 · The paper itself

Abstract

BACKGROUND AND

objectivesClinical, magnetic resonance (MR) and [

methodsWe used PET with the 5-HT

resultsIn the whole group, there was no significant (P > 0.05) correlation between epilepsy duration and AI in any region. However, in the subgroup of patients (n = 16) with mesial temporal sclerosis (MTS) a significant positive relationship between epilepsy duration and AI was found in hippocampus and parahippocampus. Patients with MTS had significantly greater hippocampus AI than patients with normal MR.

conclusionOur results further support the hypothesis that in a subset of patients epilepsy might be 'progressive' by first showing significant correlations between epilepsy duration and 5-HT

Indexed as

Epilepsy, Temporal LobeReceptor, Serotonin, 5-HT1AAdultDisease ProgressionFemaleFluorodeoxyglucose F18Hippocampal SclerosisHippocampusHumansMagnetic Resonance ImagingMaleMiddle AgedPositron-Emission TomographyYoung AdultFluorodeoxyglucose F18Receptor, Serotonin, 5-HT1A5-HT(1A) receptorEpilepsy progressionPartial volume correctionPETTemporal lobe epilepsy

Identifiers

PMID42150282
PMCPMC13202414

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.