Evidence map›Paper›PMID 42150185›Full record

ArticleBiochemistry2026

Additional Binding Domain of Marine Chitinase Increases Binding Specificity and Prolongs the Lifetime of Productive Binding State.

Hinata Tanimoto, Mikiko Tsudome, Mikako Tachioka, Atsushi Baba, Masayuki Miyazaki, Takayuki Uchihashi, Ryota Iino, Shigeru Deguchi, Akihiko Nakamura

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biochemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Hinata TanimotoDepartment of Applied Life Sciences, Faculty of Agriculture, Shizuoka University, 836 Ohya, Suruga-ku, Shizuoka 422-8529, Japan.
Mikiko TsudomeResearch Center for Bioscience and Nanoscience, Japan Agency for Marine-Earth Science and Technology (JAMSTEC), 2-15 Natsushima-cho, Yokosuka 237-0061, Japan.
Mikako TachiokaResearch Center for Bioscience and Nanoscience, Japan Agency for Marine-Earth Science and Technology (JAMSTEC), 2-15 Natsushima-cho, Yokosuka 237-0061, Japan.
Atsushi BabaResearch Center for Bioscience and Nanoscience, Japan Agency for Marine-Earth Science and Technology (JAMSTEC), 2-15 Natsushima-cho, Yokosuka 237-0061, Japan.
Masayuki MiyazakiResearch Center for Bioscience and Nanoscience, Japan Agency for Marine-Earth Science and Technology (JAMSTEC), 2-15 Natsushima-cho, Yokosuka 237-0061, Japan.
Takayuki UchihashiDepartment of Physics, Nagoya University, Nagoya, Aichi 464-8602, Japan.ORCID 0000-0002-0263-5312
Ryota IinoInstitute for Molecular Science, National Institutes of Natural Sciences, 5-1 Higashiyama Myodaijicho, Okazaki, Aichi 444-8787, Japan.ORCID 0000-0003-0110-5704
Shigeru DeguchiResearch Center for Bioscience and Nanoscience, Japan Agency for Marine-Earth Science and Technology (JAMSTEC), 2-15 Natsushima-cho, Yokosuka 237-0061, Japan.ORCID 0000-0003-0527-9824
Akihiko NakamuraDepartment of Applied Life Sciences, Faculty of Agriculture, Shizuoka University, 836 Ohya, Suruga-ku, Shizuoka 422-8529, Japan.ORCID 0000-0003-0409-5759

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In aquatic environments, insoluble polymers such as chitin are spatially heterogeneous and rapidly diluted by diffusion, posing a challenge for efficient microbial degradation. A key unresolved question is how extracellular enzymes remain associated with such substrates long enough to sustain activity. Here, we show that dual binding domains in a marine Chitinase from

Indexed as

Bacterial ProteinsCarbohydrate Binding ModulesChitinChitinasesVibrio parahaemolyticusBinding SitesCatalytic DomainKineticsMicroscopy, Atomic ForceProtein BindingProtein DomainsSubstrate SpecificityBacterial ProteinsChitinChitinases

Identifiers

PMID42150185
PMCPMC13235549

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.