Evidence map›Paper›PMID 42150126›Full record

ArticleACS nano2026

Injectable Binary-Amplified Cascade Hydrogels Suppress Post-Incomplete Microwave Ablation Relapse via Integrated Metallo-Metabolic-Immunomodulation.

Yiming Liu, Juan Qin, Kelan Fang, Hui Xu, Xuezhen Zhu, Yunfei Cai, Siyuan Wu, Peiyao Sun, Zhicheng Jin, Duo Wang and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS nano, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Yiming LiuCenter of Interventional Radiology and Vascular Surgery, Department of Radiology, Zhongda Hospital, Medical School, Southeast University, No. 87 Dingjiaqiao Road, Nanjing 210009, China.
Juan QinCenter of Interventional Radiology and Vascular Surgery, Department of Radiology, Zhongda Hospital, Medical School, Southeast University, No. 87 Dingjiaqiao Road, Nanjing 210009, China.
Kelan FangDepartment of Rehabilitation Medicine and Central Laboratory, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, No. 32, West Second Section, First Ring Road, Chengdu 610072, Sichuan, China.
Hui XuCenter of Interventional Radiology and Vascular Surgery, Department of Radiology, Zhongda Hospital, Medical School, Southeast University, No. 87 Dingjiaqiao Road, Nanjing 210009, China.
Xuezhen ZhuCenter of Interventional Radiology and Vascular Surgery, Department of Radiology, Zhongda Hospital, Medical School, Southeast University, No. 87 Dingjiaqiao Road, Nanjing 210009, China.
Yunfei CaiCenter of Interventional Radiology and Vascular Surgery, Department of Radiology, Zhongda Hospital, Medical School, Southeast University, No. 87 Dingjiaqiao Road, Nanjing 210009, China.
Siyuan WuCenter of Interventional Radiology and Vascular Surgery, Department of Radiology, Zhongda Hospital, Medical School, Southeast University, No. 87 Dingjiaqiao Road, Nanjing 210009, China.
Peiyao SunCenter of Interventional Radiology and Vascular Surgery, Department of Radiology, Zhongda Hospital, Medical School, Southeast University, No. 87 Dingjiaqiao Road, Nanjing 210009, China.
Zhicheng JinCenter of Interventional Radiology and Vascular Surgery, Department of Radiology, Zhongda Hospital, Medical School, Southeast University, No. 87 Dingjiaqiao Road, Nanjing 210009, China.
Duo WangCenter of Interventional Radiology and Vascular Surgery, Department of Radiology, Zhongda Hospital, Medical School, Southeast University, No. 87 Dingjiaqiao Road, Nanjing 210009, China.ORCID 0009-0004-4094-3326
Kun ZhangDepartment of Rehabilitation Medicine and Central Laboratory, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, No. 32, West Second Section, First Ring Road, Chengdu 610072, Sichuan, China.ORCID 0000-0002-6971-1164
Haidong ZhuCenter of Interventional Radiology and Vascular Surgery, Department of Radiology, Zhongda Hospital, Medical School, Southeast University, No. 87 Dingjiaqiao Road, Nanjing 210009, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hepatocellular carcinoma (HCC) relapse following incomplete microwave ablation (iMWA) represents a formidable clinical challenge. This progression is fueled by residual tumor cells that exhibit cell death resistance and dysregulated fatty acid metabolism, while exploiting a myeloid-derived immunosuppressive microenvironment. To address this limitation, we developed an injectable binary-amplified cascade hydrogel (S/CuCo@HD) that co-delivers CD36 inhibitor sulfosuccinimidyl oleate (SSO) and a copper-cobalt bimetal-organic framework (Cu-Co BMF). Locally administered S/CuCo@HD serves as a reservoir for sustained-release SSO and Cu-Co BMF within tumor cavities post-iMWA, provoking self-reinforced lipid oxygen radical storm by collaborative SSO-mediated fatty acid composition rewiring and peroxidase-mimetic Cu-Co BMF catalysis. The binary amplified radical reaction together with Cu

Indexed as

Antineoplastic AgentsCarcinoma, HepatocellularHydrogelsLiver NeoplasmsMicrowavesAnimalscGAS-STING Signaling PathwayCobaltCopperCuproptosisHumansImmunomodulationMiceAntineoplastic AgentsCobaltCopperHydrogelscatalytic lipid rewiringcGAS-STING pathwaycuproptosisinjectable binary-amplified cascade hydrogelmetallo-metabolic-immunomodulationself-reinforced lipid oxygen radical storm

Identifiers

PMID42150126
PMCPMC13235633

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.