Evidence map›Paper›PMID 42150082›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2026

Regulation of Pfh1 helicase activity by nucleic acid interactions and mitochondrial SSB.

María Ortiz-Rodríguez, Saurabh P Singh, Francisco J Cao-García, Roberto Galletto, Borja Ibarra

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Regulation of Pfh1 helicase activity by nucleic acid interactions and mitochondrial SSB.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

María Ortiz-RodríguezInstituto Madrileño de Estudios Avanzados en Nanociencia, Madrid 28049, Spain.
Saurabh P SinghDepartment of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St. Louis, MO 63110.
Francisco J Cao-GarcíaInstituto Madrileño de Estudios Avanzados en Nanociencia, Madrid 28049, Spain.ORCID 0000-0003-1611-913X
Roberto GallettoDepartment of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St. Louis, MO 63110.ORCID 0000-0001-6435-122X
Borja IbarraInstituto Madrileño de Estudios Avanzados en Nanociencia, Madrid 28049, Spain.ORCID 0000-0001-6597-797X

Funding

Functions of DNA helicases at hard-to-replicate sites and telomere regulationR35GM139508 · NIGMS · WASHINGTON UNIVERSITY · PI GALLETTO, ROBERTO · 2021 to 2025
$2.2M
HHS | National Institutes of Health (NIH) R35GM139508'la Caixa' Foundation ('la Caixa') HR24-00604Ministerio de Ciencia e Innovación (MCIN) PID2021-126755NB-I00Ministerio de Ciencia e Innovación (MCIN) PRE2022-102231NIGMS NIH HHS R35 GM139508
6 · The paper itself

Abstract

Pif1-family helicases are essential for proper nuclear and mitochondrial genome maintenance, yet the regulation of their activities remains incompletely understood. Here, we use single-molecule manipulation and visualization techniques to dissect the real-time mechanochemical behavior of Pfh1, the sole Pif1-family helicase in

Indexed as

DNA HelicasesDNA, MitochondrialMitochondriaSchizosaccharomycesSchizosaccharomyces pombe ProteinsAdenosine TriphosphateDNA-Binding ProteinsDNA, FungalDNA ReplicationDNA, Single-StrandedProtein BindingAdenosine TriphosphateDNA-Binding ProteinsDNA, FungalDNA HelicasesDNA, MitochondrialDNA, Single-StrandedPfh1 protein, S pombeSchizosaccharomyces pombe ProteinsATP-dependent helicase activityDNA unwinding kineticsmitochondrial SSB interactionsPfh1 helicasesingle-molecule manipulation

Identifiers

PMID42150082
PMCPMC13213944

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.