Evidence map›Paper›PMID 42150075›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2026

Attention problems and cortical maturation in a large longitudinal sample of youths: The importance of accounting for sex differences.

Shannon D O'Connor, Robert Loughnan, Jonathan Ahern, Chun Chieh Fan, Robert R Althoff, Hugh Garavan, Alexandra Potter, Matthew D Albaugh

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Shannon D O'ConnorDepartment of Psychiatry, University of Vermont, Burlington, VT 05401.ORCID 0009-0000-6946-4768
Robert LoughnanCenter for Population Neuroscience and Genetics, Laureate Institute for Brain Research, Tulsa, OK 74136.
Jonathan AhernCenter for Population Neuroscience and Genetics, Laureate Institute for Brain Research, Tulsa, OK 74136.
Chun Chieh FanCenter for Population Neuroscience and Genetics, Laureate Institute for Brain Research, Tulsa, OK 74136.ORCID 0000-0001-9437-2128
Robert R AlthoffDepartment of Psychiatry, University of Vermont, Burlington, VT 05401.
Hugh GaravanDepartment of Psychiatry, University of Vermont, Burlington, VT 05401.
Alexandra PotterDepartment of Psychiatry, University of Vermont, Burlington, VT 05401.ORCID 0000-0001-5813-6259
Matthew D AlbaughDepartment of Psychiatry, University of Vermont, Burlington, VT 05401.ORCID 0000-0002-5971-6658

Funding

ABCD-USA Consortium: Coordinating CenterU24DA041147 · NIDA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SANDRA A BROWN, TERRY L. JERNIGAN · 2015 to 2026
$54.7M
ABCD-USA Consortium: Data Analysis, Informatics and Resource CenterU24DA041123 · NIDA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ANDERS M DALE · 2015 to 2026
$51.5M
Adolescent Substance Use Initiation: Disentangling neurocognitive risks from consequences using longitudinal and genetically-informed methodsU01DA041120 · NIDA · UNIVERSITY OF MINNESOTA · PI Monica Luciana, Sylia Wilson · 2015 to 2026
$34.5M
ABCD-USA Consortium: Research ProjectU01DA041089 · NIDA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Joanna Jacobus, Susan F. Tapert · 2015 to 2026
$31.7M
Prospective Research Studies of Maturation (PRISM)- Research ProjectU01DA041134 · NIDA · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI ERIN MCGLADE, PERRY FRANKLIN RENSHAW · 2015 to 2026
$29.2M
ABCD-USA CONSORTIUM: RESEARCH PROJECTU01DA041048 · NIDA · CHILDREN'S HOSPITAL OF LOS ANGELES · PI Megan Marie Herting, ELIZABETH R SOWELL · 2015 to 2026
$28.7M
ABCD-USA Consortium: Research ProjectU01DA041106 · NIDA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Mary M Heitzeg, Chandra Sekhar Sripada · 2015 to 2026
$24.9M
FIU-ABCD: Pathways and Mechanisms to Addiction in the Latino Youth of South FloridaU01DA041156 · NIDA · FLORIDA INTERNATIONAL UNIVERSITY · PI Raul Gonzalez, Angela R Laird · 2015 to 2026
$22.8M
ABCD-USA Consortium: Research ProjectU01DA041148 · NIDA · OREGON HEALTH & SCIENCE UNIVERSITY · PI Damien A Fair, Rebekah S Huber · 2015 to 2026
$22.3M
ABCD-USA: NYC Research ProjectU01DA041174 · NIDA · YALE UNIVERSITY · PI Arielle Ryan Baskin-Sommers, Betty J Casey · 2015 to 2026
$19.7M
Adolescent Brain Cognitive Development (ABCD) Prospective Research in Studies of Maturation (PRISM) ConsortiumU01DA041117 · NIDA · UNIVERSITY OF MARYLAND BALTIMORE · PI LINDA CHANG, THOMAS M ERNST · 2015 to 2026
$19.5M
15/21 ABCD-USA Consortium: Research Project Site at LIBRU01DA050989 · NIDA · LAUREATE INSTITUTE FOR BRAIN RESEARCH · PI ROBIN L AUPPERLE, MARTIN P. PAULUS · 2020 to 2026
$14.7M
Foundation for the National Institutes of Health (FNIH) U01DA041022Foundation for the National Institutes of Health (FNIH) U01DA041025Foundation for the National Institutes of Health (FNIH) U01DA041028Foundation for the National Institutes of Health (FNIH) U01DA041048Foundation for the National Institutes of Health (FNIH) U01DA041089Foundation for the National Institutes of Health (FNIH) U01DA041093Foundation for the National Institutes of Health (FNIH) U01DA041106Foundation for the National Institutes of Health (FNIH) U01DA041117Foundation for the National Institutes of Health (FNIH) U01DA041120Foundation for the National Institutes of Health (FNIH) U01DA041134Foundation for the National Institutes of Health (FNIH) U01DA041148Foundation for the National Institutes of Health (FNIH) U01DA041156Foundation for the National Institutes of Health (FNIH) U01DA041174Foundation for the National Institutes of Health (FNIH) U01DA050987Foundation for the National Institutes of Health (FNIH) U01DA050988Foundation for the National Institutes of Health (FNIH) U01DA050989Foundation for the National Institutes of Health (FNIH) U01DA051016Foundation for the National Institutes of Health (FNIH) U01DA051018Foundation for the National Institutes of Health (FNIH) U01DA051037Foundation for the National Institutes of Health (FNIH) U01DA051038Foundation for the National Institutes of Health (FNIH) U01DA051039Foundation for the National Institutes of Health (FNIH) U24DA041123Foundation for the National Institutes of Health (FNIH) U24DA041147National Institute of Mental Health and Neurosciences (NIMHANS) MH121654
6 · The paper itself

Abstract

Delayed age-related cortical thinning has been proposed as a biomarker of attention-related psychopathology and attention-deficit/hyperactivity disorder (ADHD), but these findings have not been adequately replicated in large, longitudinal samples with sufficient power to account for potential confounds such as co-occurring psychopathology and sex differences in neurodevelopment. Here, we examined whether previously reported associations between attention problems and delayed cortical thickness development could be replicated in a large, longitudinal cohort of youths. Leveraging data from the Adolescent Brain Cognitive Development Study, linear mixed-effects models were used to assess the association between parent-reported attention problems (AP) on the Child Behavior Checklist and age-related cortical thickness change (N = 26,496 MRI scans from 11,025 unique participants). Secondary analyses examined the association between a polygenic risk score for ADHD and cortical thickness development. In initial sex-pooled analyses, we observed associations between AP and reduced rates of cortical thinning (β = 00594 to 0.0145, FDR-adjusted

Indexed as

AttentionAttention Deficit Disorder with HyperactivityCerebral CortexAdolescentChildFemaleHumansLongitudinal StudiesMagnetic Resonance ImagingMaleNeurodevelopmentSex CharacteristicsSex FactorsADHDadolescentattention problemsneurodevelopmentneuroimaging

Identifiers

PMID42150075
PMCPMC13213984

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.