Evidence map›Paper›PMID 42150070›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2026

Spatially tunable multiomic sequencing using light-driven combinatorial barcoding of molecules in tissues.

Giorgia Battistoni, Sito Torres-Garcia, Chee Ying Sia, Silvia Corriero, Carla Boquetale, Elena Williams, Anna Cregeen, Karolina Wasilewska, Martina Alini, Nicole Hemmer and 5 more

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Giorgia Battistoni *Cancer Research UK Cambridge Institute, University of Cambridge, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, United Kingdom.
Sito Torres-Garcia *Cancer Research UK Cambridge Institute, University of Cambridge, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, United Kingdom.
Chee Ying SiaCancer Research UK Cambridge Institute, University of Cambridge, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, United Kingdom.
Silvia CorrieroCancer Research UK Cambridge Institute, University of Cambridge, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, United Kingdom.
Carla BoquetaleCancer Research UK Cambridge Institute, University of Cambridge, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, United Kingdom.
Elena WilliamsCancer Research UK Cambridge Institute, University of Cambridge, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, United Kingdom.
Anna CregeenCancer Research UK Cambridge Institute, University of Cambridge, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, United Kingdom.
Karolina WasilewskaCancer Research UK Cambridge Institute, University of Cambridge, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, United Kingdom.
Martina AliniCancer Research UK Cambridge Institute, University of Cambridge, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, United Kingdom.
Nicole HemmerCancer Research UK Cambridge Institute, University of Cambridge, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, United Kingdom.
IMAXT Cancer Grand Challenge Consortium
Shankar BalasubramanianCancer Research UK Cambridge Institute, University of Cambridge, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, United Kingdom.ORCID 0000-0002-0281-5815
Benjamin Czech NicholsonCancer Research UK Cambridge Institute, University of Cambridge, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, United Kingdom.
Gregory J HannonCancer Research UK Cambridge Institute, University of Cambridge, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, United Kingdom.
Dario BressanCancer Research UK Cambridge Institute, University of Cambridge, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, United Kingdom.ORCID 0000-0003-3592-699X

Funding

Branco Weiss Fellowship - Society in Science n/aCancer Research UK (CRUK) A21143Cancer Research UK (CRUK) A24042Cancer Research UK (CRUK) G104344NIHR | NIHR Cambridge Biomedical Research Centre (NIHR Cambridge BRC) BRC-1215-20014Royal Society (The Royal Society) RSRP\R \ 200001Wellcome Trust (WT) 110161/Z/15/ZWellcome Trust (WT) 209441/Z/17.Z
6 · The paper itself

Abstract

Mapping the molecular identities and functions of cells within their spatial context is key to understanding the complex interplay within and between tissue neighborhoods. A wide range of methods have recently enabled spatial profiling of cellular anatomical contexts, some offering single-cell resolution. These use different barcoding schemes to encode either the location or the identity of target molecules. However, all these technologies face a trade-off between spatial resolution, depth of profiling, and scalability. Here, we present

Indexed as

High-Throughput Nucleotide SequencingAnimalsBrainChromatinGene Expression ProfilingMiceMultiomicsSpatial TranscriptomicsTranscriptomeChromatinchromatin accessibilityRNA expressionspatial profiling

Identifiers

PMID42150070
PMCPMC13214022

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.