Evidence map›Paper›PMID 42150039›Full record

ArticleLasers in surgery and medicine2026

Light Source Matching Strategies for Optimal Treatment Efficacy of HMME and m-THPC in Photodynamic Therapy of Vascular Lesions.

Zhewen Song, Shuiting Fu, Yan Liu, Guoyu Zhou, Ting Zhu

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Lasers in surgery and medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Zhewen SongDepartment of Oral and Maxillofacial-Head Neck Oncology, Department of Laser and Aesthetic Medicine, Shanghai Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Shuiting FuDepartment of Oral and Maxillofacial-Head Neck Oncology, Department of Laser and Aesthetic Medicine, Shanghai Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Yan LiuDepartment of Health, 940 Hospital of PLA Joint Logistic Support, Lanzhou, China.
Guoyu ZhouDepartment of Oral and Maxillofacial-Head Neck Oncology, Department of Laser and Aesthetic Medicine, Shanghai Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Ting ZhuDepartment of Oral and Maxillofacial-Head Neck Oncology, Department of Laser and Aesthetic Medicine, Shanghai Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, Shanghai, China.ORCID https://orcid.org/0009-0006-7413-7212

Funding

Clinical Medical Research Center Project of Hainan Provincial Department of Science and Technology LCYX202108Interdisciplinary Program of Shanghai Jiao Tong University YG2022QN050National Natural Science Foundation of China 82003177Projects of the National Clinical Research Center for Oral Diseases NCRC0202105Shanghai Sailing Program 20YF1424200
6 · The paper itself

Abstract

objectiveThis study aims to compare the therapeutic effects of hematoporphyrin monomethyl ether (HMME) and meta-tetrahydroxyphenylchlorin (m-THPC) under single-wavelength and dual-wavelength light irradiation in photodynamic therapy (PDT), and aims to optimize light source matching strategies to enhance targeted treatment of vascular lesions.

methodsThis study employed the ABDA probe assay to evaluate the in vitro reactive oxygen species (ROS) generation efficiency of two photosensitizers (HMME and m-THPC) under 410, 532, 653 nm, and dual-wavelength (410 + 653 nm) irradiation. Using Leghorn chicken comb as a vascular malformation model, we further assessed in vivo vascular damage effects, thermal responses, tissue-level ROS production, and apoptosis rates.

resultsThis study demonstrated that HMME exhibited optimal photodynamic efficacy at 410 nm, while m-THPC maintained substantial photodynamic efficacy at both 410 and 653 nm, with the dual-wavelength combination (410 + 653 nm) showing complementary activation for m-THPC but reduced efficacy for HMME. The 532 nm wavelength, though effective for vascular damage, caused significant thermal injury and non-specific apoptosis of non-target cells, highlighting its clinical limitations. Histopathological analysis confirmed that 410 and 653 nm irradiation selectively targeted vasculature with minimal epidermal damage, whereas 532 nm led to widespread tissue necrosis. ROS generation and apoptotic assays revealed that HMME's cytotoxicity was strongest at 410 nm, while m-THPC performed well across multiple wavelengths, and particularly benefited from dual-wavelength activation.

conclusionPhotosensitizer activation efficiency is highly wavelength-dependent, with HMME performing best at shorter wavelengths (410 nm) while m-THPC maintains considerable efficacy at longer wavelengths (653 nm). The dual-wavelength combination (410 + 653 nm) can partially overcome limitations of single wavelengths, providing references for clinical light source optimization.

Indexed as

HematoporphyrinsMesoporphyrinsPhotochemotherapyPhotosensitizing AgentsAnimalsApoptosisChickensReactive Oxygen Specieshematoporphyrin monomethyl etherHematoporphyrinsMesoporphyrinsPhotosensitizing AgentsReactive Oxygen Speciestemoporfinchicken combphotodynamic therapyphotosensitizerreactive oxygen specieswavelength

Identifiers

PMID42150039
PMCPMC13465996

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.